In-depth N-glycome profiling of paired colorectal cancer and non-tumorigenic tissues reveals cancer-, stage- and EGFR-specific protein N-glycosylation.

PubMed Entry

GlyToucan Accession Number: G11654TG

Peak Intensity
416.1 199.0
468.2 118.0

Annotations:

C^{2,5}X_{NeuAc} C^{2,5}X_{NeuAc}
536.2 264.0
553.1 212.0

Annotations:

Z
572.1 298.0

Annotations:

^{0,2}A_{GlcNAc} C^{2,4}X_{NeuAc} C^{2,4}X_{NeuAc} ^{0,2}A_{GlcNAc}
649.1 383.0

Annotations:

^{1,5}A_{GlcNAc}Z ^{1,5}A_{GlcNAc}Z
653.2 192.0
654.3 208.0
655.1 102.0

Annotations:

B B
656.4 363.0

Annotations:

^{1,5}X_{NeuAc}Z Z^{1,5}X_{NeuAc} Z^{1,4}X_{Man} ^{1,4}X_{Man}Z Z^{0,3}X_{Gal} ^{1,4}X_{Gal}Z ^{1,4}X_{GlcNAc}Z
673.1 610.0

Annotations:

C C
674.3 342.0
754.8 376.0
817.3 103.0

Annotations:

B B
835.3 432.0

Annotations:

C C
836.3 109.0
854.9 278.0

Annotations:

^{2,4}X_{GlcNAc}Y ^{2,4}X_{GlcNAc}Y ^{2,5}X_{NeuAc}Y Y^{2,5}X_{NeuAc}
867.2 136.0

Annotations:

ZZ ZZ
875.9 238.0

Annotations:

YZ ZY YZ ZY
876.4 187.0

Annotations:

B^{1,3}X_{NeuAc} B^{1,3}X_{NeuAc}
876.8 154.0
905.9 170.0

Annotations:

^{0,2}X_{Gal}Y Y^{0,2}X_{Fuc} ^{0,2}X_{Gal}Y Y^{0,2}X_{Fuc} ^{2,5}X_{GlcNAc} ^{2,5}X_{GlcNAc} C^{2,5}X_{NeuAc} C^{2,5}X_{NeuAc}
906.4 674.0

Annotations:

C^{2,5}X_{NeuAc} C^{2,5}X_{NeuAc}
907.3 417.0

Annotations:

C
907.8 752.0

Annotations:

C
908.3 171.0
909.4 109.0
936.3 412.0

Annotations:

^{0,4}X_{Gal}Y Y^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Y ^{1,3}X_{Gal}Y ^{2,4}X_{Gal}Y Y^{0,4}X_{Fuc} Y^{1,3}X_{NeuAc} ^{2,5}X_{NeuAc}Y Y^{2,5}X_{NeuAc}
957.9 1411.0

Annotations:

Y Y
958.3 310.0

Annotations:

Y Y
967.3 579.0

Annotations:

Y^{1,4}X_{GlcNAc} ^{1,4}X_{Man}Y
989.0 342.0
999.0 147.0
999.7 349.0

Annotations:

B
1000.4 229.0

Annotations:

^{0,2}X_{NeuAc}Y Z^{3,5}X_{Fuc} ^{0,2}X_{NeuAc}Y Z^{3,5}X_{Fuc}
1012.5 706.0
1013.9 135.0
1030.4 330.0
1030.9 241.0
1031.9 1029.0
1036.8 267.0
1038.8 680.0

Annotations:

Y Y
1039.0 642.0

Annotations:

Y Y
1039.4 319.0

Annotations:

YZ
1040.0 421.0
1046.8 525.0
1050.8 127.0
1056.0 149.0
1060.1 187.0
1067.9 218.0
1074.3 162.0

Annotations:

^{0,2}X_{NeuAc} ^{0,2}X_{NeuAc}
1084.3 101.0
1111.4 618.0

Annotations:

Y
1111.9 842.0

Annotations:

Z^{1,4}X_{GlcNAc}
1113.0 193.0
1113.3 845.0
1125.0 104.0

Annotations:

^{1,5}X_{Fuc}
1126.2 231.0

Annotations:

Y^{1,5}X_{Gal} ^{1,5}X_{Man}Y
1127.5 221.0
1133.5 268.0

Annotations:

^{2,4}X_{NeuAc} ^{2,4}X_{NeuAc}
1134.0 589.0

Annotations:

^{2,4}X_{NeuAc} ^{2,4}X_{NeuAc}
1145.6 331.0
1145.9 1417.0
1146.4 1024.0
1146.9 277.0
1153.3 182.0
1154.4 1566.0

Annotations:

^{1,5}A_{GlcNAc}Y ^{1,5}A_{GlcNAc}Y ^{1,3}X_{Fuc} ^{2,4}X_{Fuc}
1155.0 1523.0

Annotations:

^{3,5}X_{Fuc}
1155.4 670.0

Annotations:

^{3,5}X_{Fuc}
1155.9 770.0

Annotations:

^{3,5}X_{Fuc}
1164.3 304.0

Annotations:

BZ BZ
1167.1 543.0
1168.8 249.0

Annotations:

Z^{3,5}X_{Gal} Z^{3,5}X_{GlcNAc}
1169.6 176.0

Annotations:

B^{1,5}X_{GlcNAc} B^{1,5}X_{GlcNAc}
1174.5 645.0
1174.9 1028.0
1175.4 4878.0
1176.0 2099.0
1176.4 2601.0
1176.9 543.0
1177.1 926.0
1177.5 634.0
1177.8 440.0
1183.5 3753.0

Annotations:

^{2,4}A_{GlcNAc}Z ^{2,4}A_{GlcNAc}Z
1183.9 1711.0
1184.5 2970.0
1257.6 112.0
1363.6 126.0
1465.6 208.0
1507.5 104.0

Annotations:

^{1,3}X_{NeuAc}Y ^{1,3}X_{Man}Y ^{1,3}X_{Man}Y Y^{0,4}X_{Fuc} Y^{0,4}X_{Fuc} Y^{1,3}X_{NeuAc}
1524.6 123.0

Annotations:

CY CY
1551.6 438.0

Annotations:

Y Y
1552.7 181.0
1553.5 185.0
1553.6 289.0
1566.4 171.0

Annotations:

^{2,4}A_{GlcNAc}Y ^{2,4}A_{GlcNAc}Y
1567.7 179.0

Annotations:

YY YY
1568.6 144.0
1592.7 106.0

Annotations:

B^{2,5}X_{NeuAc} B^{2,5}X_{NeuAc} ^{2,5}A_{GlcNAc}Z ^{2,5}A_{GlcNAc}Z
1604.5 266.0
1622.7 251.0

Annotations:

B^{3,5}X_{NeuAc} B^{3,5}X_{NeuAc}
1625.6 267.0

Annotations:

YY YY
1626.5 115.0

Annotations:

^{0,2}A_{GlcNAc}Y ^{0,2}A_{GlcNAc}Y
1627.7 262.0
1694.5 174.0
1709.7 124.0

Annotations:

BY BY CZ CZ
1713.7 348.0

Annotations:

Y Y
1713.9 313.0

Annotations:

Y Y
1714.6 248.0

Annotations:

C^{2,4}X_{NeuAc} C^{2,4}X_{NeuAc}
1715.6 121.0
1719.8 582.0
1755.5 402.0
1758.3 185.0
1773.8 321.0
1787.7 154.0

Annotations:

YY
1788.6 105.0
1790.0 281.0
1790.6 150.0
1799.6 112.0

Annotations:

C^{1,5}X_{NeuAc} C^{1,5}X_{NeuAc}
1862.6 276.0
1881.4 120.0
1881.8 100.0
1898.8 268.0

Annotations:

Z Z
1899.6 112.0

Annotations:

B^{2,4}X_{NeuAc} B^{2,4}X_{NeuAc}
1901.6 378.0

Annotations:

^{2,5}A_{GlcNAc}
1915.7 230.0
1916.8 1011.0

Annotations:

Y Y
1917.7 431.0

Annotations:

C^{2,4}X_{NeuAc} C^{2,4}X_{NeuAc} ^{0,2}A_{GlcNAc}
1919.0 312.0
1945.8 163.0

Annotations:

^{1,4}X_{NeuAc}Z Z^{1,4}X_{NeuAc}
2059.7 145.0
2060.7 659.0

Annotations:

Z Z
2061.0 415.0

Annotations:

Z Z
2061.2 253.0

Annotations:

Z Z
2061.8 394.0
2062.9 173.0
2063.7 739.0
2064.9 267.0
2077.6 126.0
2078.9 5254.0

Annotations:

Y Y
2079.5 355.0
2079.8 7574.0
2080.8 4382.0
2081.9 1849.0
2082.8 973.0
2083.7 425.0
2120.8 141.0

There are 9 similar spectra:

Id Structure Score

2562

1.00

2584

0.91

2563

0.91

2410

0.81

2409

0.79

2261

0.61

2582

0.59

2561

0.59

389

0.59
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