Cystic fibrosis and bacterial colonization define the sputum N-glycosylation phenotype

PubMed Entry

GlyToucan Accession Number: G11654TG

Peak Intensity
324.0 159.0

Annotations:

Y^{0,4}X_{Fuc}
350.0 511.0

Annotations:

Z
350.2 402.0

Annotations:

Z
368.2 745.0

Annotations:

Y
452.3 156.0

Annotations:

B B
456.6 325.0
470.1 276.0

Annotations:

C C
471.3 1216.0
511.1 241.0

Annotations:

Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} ^{2,4}X_{GlcNAc}
554.2 444.0

Annotations:

B^{2,4}X_{NeuAc} B^{2,4}X_{NeuAc} ^{1,4}A_{GlcNAc}Y ^{1,4}A_{GlcNAc}Y
571.3 334.0

Annotations:

Y
613.3 300.0

Annotations:

C^{1,5}X_{Man} ^{2,5}A_{GlcNAc}Z ^{2,5}A_{GlcNAc}Z C^{1,5}X_{Man}
673.4 1080.0

Annotations:

C C
688.3 426.0
721.8 424.0

Annotations:

YZ
735.8 855.0

Annotations:

B^{3,5}X_{GlcNAc} B^{3,5}X_{GlcNAc} Z^{1,3}X_{Fuc} Z^{2,4}X_{Fuc} Z^{1,3}X_{Fuc} Z^{2,4}X_{Fuc} Z^{1,5}X_{Gal} ^{1,5}X_{Gal}Z
741.1 643.0
753.9 148.0

Annotations:

^{2,5}X_{NeuAc}Y Y^{2,5}X_{NeuAc}
762.3 970.0
764.2 289.0

Annotations:

BZ BZ
773.8 575.0

Annotations:

YZ ZY YZ ZY
774.2 401.0

Annotations:

YZ ZY YZ ZY
778.0 108.0
782.8 747.0

Annotations:

YY YY
783.2 768.0

Annotations:

YY YY
796.3 391.0

Annotations:

C^{0,2}X_{NeuAc} ^{2,4}X_{NeuAc}Z Z^{2,4}X_{NeuAc} C^{1,5}X_{Gal} C^{1,5}X_{Gal} ^{0,4}X_{NeuAc}Y Y^{0,4}X_{NeuAc} C^{0,2}X_{NeuAc}
810.6 302.0

Annotations:

^{1,4}X_{GlcNAc}Z ^{1,4}X_{GlcNAc}Z Z^{0,3}X_{Fuc} Z^{0,3}X_{Fuc} B^{3,5}X_{NeuAc} B^{3,5}X_{NeuAc}
817.5 600.0

Annotations:

B B
818.7 463.0

Annotations:

^{1,4}A_{GlcNAc}Y ^{1,4}A_{GlcNAc}Y C^{0,3}X_{Gal} C^{1,4}X_{Gal} Z^{3,5}X_{Fuc} Z^{3,5}X_{Fuc}
826.3 454.0

Annotations:

C^{3,5}X_{Gal} Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} Y^{1,5}X_{Gal} Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} ^{1,3}X_{Man} ^{1,5}X_{Gal}Y ^{1,3}X_{Man}
835.2 734.0

Annotations:

C C
835.5 709.0

Annotations:

C C
836.8 350.0
838.3 250.0

Annotations:

Z^{0,2}X_{NeuAc} ^{3,5}X_{GlcNAc}Z ^{3,5}X_{GlcNAc}Z B^{0,4}X_{NeuAc} B^{0,4}X_{NeuAc} ^{0,2}X_{NeuAc}Z
844.1 302.0
845.0 215.0

Annotations:

BZ BZ
845.7 632.0

Annotations:

BZ BZ
846.0 652.0

Annotations:

^{2,4}X_{GlcNAc}Z ^{2,4}X_{GlcNAc}Z ^{2,5}X_{NeuAc}Z Z^{2,5}X_{NeuAc}
847.3 794.0

Annotations:

Z Z
847.9 304.0

Annotations:

B^{2,4}X_{NeuAc} B^{2,4}X_{NeuAc} ^{3,5}X_{GlcNAc}Y ^{3,5}X_{GlcNAc}Y ^{1,5}X_{NeuAc}Y Y^{1,5}X_{NeuAc} Y^{0,3}X_{Gal} ^{1,4}X_{Gal}Y
848.5 152.0

Annotations:

^{1,5}X_{NeuAc}Y Y^{1,5}X_{NeuAc} Y^{0,3}X_{Gal} ^{1,4}X_{Gal}Y
856.3 274.0

Annotations:

Y Y
856.8 188.0

Annotations:

Y Y
885.8 638.0
898.3 210.0

Annotations:

B
900.4 613.0

Annotations:

^{1,4}X_{NeuAc}Y Y^{1,4}X_{NeuAc}
908.4 1253.0
908.8 1675.0
920.5 201.0

Annotations:

^{1,5}X_{NeuAc}Z Z^{1,5}X_{NeuAc} ^{0,3}X_{Gal}Y Y^{0,3}X_{Fuc} ^{3,5}X_{GlcNAc} ^{1,4}X_{Gal}Y Y^{0,3}X_{Fuc} ^{3,5}X_{GlcNAc}
921.3 357.0

Annotations:

^{0,3}X_{Gal}Y Y^{0,3}X_{Fuc} ^{3,5}X_{GlcNAc} ^{1,4}X_{Gal}Y Y^{0,3}X_{Fuc} ^{3,5}X_{GlcNAc} C^{3,5}X_{NeuAc} C^{3,5}X_{NeuAc}
927.3 687.0

Annotations:

^{0,4}X_{Gal}Z Z^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Z ^{1,3}X_{Gal}Z ^{2,4}X_{Gal}Z Z^{0,4}X_{Fuc} Z^{1,3}X_{NeuAc} ^{2,5}X_{NeuAc}Z Z^{2,5}X_{NeuAc}
928.9 623.0

Annotations:

Y^{3,5}X_{Fuc} ^{3,5}X_{Gal}Y Y^{3,5}X_{Fuc} ^{1,5}X_{NeuAc}Y Y^{1,5}X_{NeuAc}
929.4 8407.0

Annotations:

^{1,5}X_{NeuAc}Y Y^{1,5}X_{NeuAc}
929.9 3400.0
930.4 2005.0
930.8 107.0
931.1 485.0
935.6 643.0

Annotations:

^{3,5}A_{GlcNAc} ^{0,4}X_{Gal}Y Y^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Y ^{1,3}X_{Gal}Y ^{2,4}X_{Gal}Y Y^{0,4}X_{Fuc} Y^{1,3}X_{NeuAc}
936.9 984.0
957.4 327.0

Annotations:

Y Y
957.8 1045.0

Annotations:

Y Y
958.0 1586.0

Annotations:

Y Y
958.5 1176.0

Annotations:

C^{2,4}X_{NeuAc} C^{2,4}X_{NeuAc} ^{0,2}A_{GlcNAc}
958.8 847.0

Annotations:

C^{2,4}X_{NeuAc} C^{2,4}X_{NeuAc} ^{0,2}A_{GlcNAc}
963.4 549.0

Annotations:

^{1,4}A_{GlcNAc}
976.9 534.0
977.3 649.0
979.3 369.0

Annotations:

BY BY CZ CZ
981.5 397.0

Annotations:

^{1,4}X_{NeuAc}Y Y^{1,4}X_{NeuAc}
983.4 500.0
991.8 193.0

Annotations:

^{0,2}X_{NeuAc}Z ^{0,2}X_{NeuAc}Z
992.4 1226.0

Annotations:

^{1,5}X_{NeuAc}Z ^{1,5}X_{NeuAc}Z Z^{0,3}X_{Fuc} Z^{0,3}X_{Fuc}
997.9 1631.0
998.5 473.0
998.9 111.0
1000.3 514.0

Annotations:

B
1000.7 1388.0

Annotations:

^{0,2}X_{NeuAc}Y Z^{3,5}X_{Fuc} ^{0,2}X_{NeuAc}Y Z^{3,5}X_{Fuc}
1003.8 877.0
1006.2 183.0

Annotations:

Z^{3,5}X_{GlcNAc}
1009.3 321.0

Annotations:

C
1013.0 1042.0
1013.4 449.0
1013.7 323.0
1013.9 238.0
1017.8 416.0
1021.8 198.0

Annotations:

ZZ
1022.3 202.0
1024.5 355.0

Annotations:

Y^{3,5}X_{GlcNAc}
1028.8 1168.0
1032.0 140.0
1032.5 231.0
1037.4 583.0
1037.8 380.0
1038.3 542.0

Annotations:

Y^{2,4}X_{GlcNAc}
1038.9 604.0

Annotations:

Y Y
1039.4 2033.0

Annotations:

YZ
1040.1 1119.0
1040.5 1147.0
1041.1 371.0
1041.4 379.0
1057.6 758.0

Annotations:

YY
1058.5 249.0
1060.0 112.0
1061.6 976.0
1074.4 349.0

Annotations:

^{1,5}X_{NeuAc} ^{1,5}X_{NeuAc}
1075.1 1219.0

Annotations:

^{1,5}X_{NeuAc} ^{1,5}X_{NeuAc}
1075.4 346.0
1100.2 260.0
1102.5 988.0

Annotations:

Z
1102.9 1439.0
1103.4 1575.0
1103.9 305.0
1104.3 1385.0
1105.9 487.0
1108.3 220.0

Annotations:

Z^{1,5}X_{Gal} ^{1,5}X_{Man}Z
1124.2 230.0

Annotations:

^{0,4}X_{NeuAc} ^{0,4}X_{NeuAc}
1125.0 1116.0

Annotations:

^{1,5}X_{Fuc}
1125.5 1163.0

Annotations:

^{1,5}X_{Fuc}
1126.3 150.0

Annotations:

Y^{1,5}X_{Gal} ^{1,5}X_{Man}Y
1126.7 769.0

Annotations:

Y^{1,5}X_{Gal} ^{1,5}X_{Man}Y ^{1,4}X_{NeuAc} ^{1,4}X_{NeuAc}
1130.4 597.0
1135.0 343.0
1141.5 502.0

Annotations:

BY BY CZ CZ
1145.6 433.0
1145.9 1511.0
1146.2 323.0
1146.5 691.0
1146.8 836.0
1148.5 286.0
1152.5 410.0

Annotations:

Z^{0,3}X_{Gal} ^{1,4}X_{Gal}Z ^{1,4}X_{Man}Z Z^{0,3}X_{GlcNAc}
1154.3 508.0

Annotations:

^{1,5}A_{GlcNAc}Y ^{1,5}A_{GlcNAc}Y ^{1,3}X_{Fuc} ^{2,4}X_{Fuc}
1154.5 650.0

Annotations:

^{1,5}A_{GlcNAc}Y ^{1,5}A_{GlcNAc}Y ^{1,3}X_{Fuc} ^{2,4}X_{Fuc}
1155.0 3447.0

Annotations:

^{3,5}X_{Fuc}
1155.6 1342.0

Annotations:

^{3,5}X_{Fuc}
1156.0 344.0

Annotations:

Y^{2,5}X_{Gal} Y^{2,5}X_{GlcNAc}
1156.5 1288.0

Annotations:

Y^{2,5}X_{Gal} Y^{2,5}X_{GlcNAc}
1163.0 487.0
1163.4 487.0
1163.9 396.0

Annotations:

BZ BZ
1166.0 109.0
1168.8 146.0

Annotations:

Z^{3,5}X_{Gal} Z^{3,5}X_{GlcNAc}
1174.7 353.0
1175.4 4798.0
1176.0 5685.0
1176.4 2788.0
1176.9 807.0
1177.0 825.0
1224.4 290.0

Annotations:

ZZ ZZ ZZ
1244.3 210.0
1278.5 385.0
1288.8 143.0

Annotations:

C^{3,5}X_{GlcNAc} C^{3,5}X_{GlcNAc} Y^{1,5}X_{Man} ^{1,5}X_{Man}Y Y^{1,5}X_{Gal} ^{1,5}X_{GlcNAc}Y ^{1,5}X_{Gal}Y
1301.9 113.0
1314.6 329.0

Annotations:

^{1,5}X_{NeuAc}Z Z^{1,5}X_{NeuAc} Z^{1,4}X_{Man} ^{1,4}X_{Man}Z Z^{0,3}X_{Gal} ^{1,4}X_{Gal}Z ^{1,4}X_{GlcNAc}Z
1387.5 503.0

Annotations:

YZ ZY YZ ZY
1407.3 569.0
1407.5 778.0
1430.4 203.0

Annotations:

^{2,5}A_{GlcNAc}Z ^{2,5}A_{GlcNAc}Z
1464.6 127.0

Annotations:

^{0,2}A_{GlcNAc}Y ^{0,2}A_{GlcNAc}Y C^{0,4}X_{Gal} C^{1,3}X_{Gal} C^{2,4}X_{Gal}
1469.7 152.0
1474.3 787.0

Annotations:

^{0,2}X_{NeuAc}Z Z^{0,2}X_{NeuAc}
1495.6 306.0
1510.4 287.0
1524.6 345.0

Annotations:

CY CY
1526.5 476.0
1527.6 431.0
1542.5 261.0
1566.5 448.0

Annotations:

^{2,4}A_{GlcNAc}Y ^{2,4}A_{GlcNAc}Y
1567.5 441.0

Annotations:

YY YY
1568.5 408.0
1568.8 617.0
1569.4 381.0
1569.6 257.0
1569.8 155.0
1570.6 407.0
1584.5 174.0
1593.5 204.0

Annotations:

C^{1,5}X_{Gal} C^{1,5}X_{Gal} ^{0,4}X_{NeuAc}Y Y^{0,4}X_{NeuAc}
1625.5 511.0

Annotations:

YY YY
1636.7 206.0
1666.8 173.0

Annotations:

^{2,5}X_{GlcNAc}Y ^{2,5}X_{GlcNAc}Y
1678.5 383.0

Annotations:

^{3,5}X_{GlcNAc}Z ^{3,5}X_{GlcNAc}Z
1709.6 279.0

Annotations:

BY BY CZ CZ
1710.6 190.0

Annotations:

^{2,4}X_{GlcNAc}Y ^{2,4}X_{GlcNAc}Y
1713.6 215.0

Annotations:

Y Y
1714.6 504.0

Annotations:

C^{2,4}X_{NeuAc} C^{2,4}X_{NeuAc}
1717.1 191.0
1717.7 139.0
1718.6 192.0
1719.6 193.0
1735.7 373.0
1736.8 495.0
1737.5 340.0
1779.6 242.0

Annotations:

B^{0,2}X_{NeuAc} B^{0,2}X_{NeuAc}
1787.7 945.0

Annotations:

YY
1788.6 221.0
1788.9 314.0
1789.8 820.0
1790.4 1210.0
1790.6 886.0
1797.6 298.0

Annotations:

B
1798.7 1008.0

Annotations:

Y^{1,5}X_{Fuc} Y^{1,5}X_{Fuc} ^{1,5}X_{Gal}Y ^{1,5}X_{Gal}Y
1799.6 531.0

Annotations:

C^{1,5}X_{NeuAc} C^{1,5}X_{NeuAc}
1805.9 121.0
1816.6 384.0
1816.8 1052.0
1817.5 610.0
1818.6 340.0
1819.8 237.0
1820.8 212.0
1841.7 670.0

Annotations:

^{1,5}X_{NeuAc}Z Z^{1,5}X_{NeuAc}
1842.0 659.0

Annotations:

^{1,5}X_{NeuAc}Z Z^{1,5}X_{NeuAc}
1842.7 780.0

Annotations:

^{0,3}X_{Gal}Y Y^{0,3}X_{Fuc} ^{3,5}X_{GlcNAc} ^{1,4}X_{Gal}Y Y^{0,3}X_{Fuc} ^{3,5}X_{GlcNAc}
1843.8 418.0

Annotations:

C^{3,5}X_{NeuAc} C^{3,5}X_{NeuAc}
1859.6 1267.0

Annotations:

^{1,5}X_{NeuAc}Y Y^{1,5}X_{NeuAc}
1860.5 1158.0
1860.8 1009.0
1861.7 405.0
1862.0 908.0
1863.1 160.0
1880.0 144.0
1884.9 229.0
1898.7 872.0

Annotations:

Z Z
1916.7 735.0

Annotations:

Y Y
1917.1 398.0

Annotations:

Y Y
1917.7 369.0

Annotations:

C^{2,4}X_{NeuAc} C^{2,4}X_{NeuAc} ^{0,2}A_{GlcNAc}
1917.9 417.0

Annotations:

C^{2,4}X_{NeuAc} C^{2,4}X_{NeuAc} ^{0,2}A_{GlcNAc}
1918.7 505.0
1919.6 221.0
1957.9 117.0
2001.7 413.0
2002.8 461.0

Annotations:

^{0,2}X_{NeuAc}Y Z^{3,5}X_{Fuc} ^{0,2}X_{NeuAc}Y Z^{3,5}X_{Fuc}
2004.6 469.0

Annotations:

^{1,5}X_{NeuAc}Y ^{1,5}X_{NeuAc}Y Y^{0,3}X_{Fuc} ^{3,5}X_{Gal} Y^{0,3}X_{Fuc}
2027.8 608.0
2028.5 610.0
2028.8 527.0
2029.8 135.0
2060.8 2517.0

Annotations:

Z Z
2061.7 737.0
2062.0 2057.0
2062.7 330.0
2063.2 499.0
2063.7 237.0
2064.7 1846.0
2077.9 451.0
2078.8 9290.0

Annotations:

Y Y
2079.7 5430.0
2080.9 5236.0
2081.7 3360.0
2082.7 815.0
2083.1 394.0
2083.8 401.0
2121.7 230.0

There are 7 similar spectra:

Id Structure Score

2409

0.70

2410

0.70

2259

0.65

2563

0.63

2584

0.63

2562

0.61

2583

0.61
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