In-depth N-glycome profiling of paired colorectal cancer and non-tumorigenic tissues reveals cancer-, stage- and EGFR-specific protein N-glycosylation.

PubMed Entry

GlyToucan Accession Number: G74026TS

Peak Intensity
368.2 1324.0

Annotations:

Y
452.3 458.0

Annotations:

B
470.3 166.0

Annotations:

C
471.1 442.0
490.3 111.0
512.2 334.0

Annotations:

^{2,4}A_{GlcNAc} C^{1,5}X_{Man} C^{1,5}X_{Man}
536.1 232.0
536.3 142.0
553.1 139.0

Annotations:

Z
614.1 199.0

Annotations:

C^{1,5}X_{Man} C^{1,5}X_{Man} C^{0,2}X_{NeuAc} C^{0,2}X_{NeuAc}
653.3 613.0
655.3 505.0

Annotations:

B
673.4 1003.0

Annotations:

C
674.3 155.0
742.3 156.0
783.8 134.0
795.4 429.0

Annotations:

Z^{0,2}X_{Fuc} Z^{0,2}X_{Fuc} B^{2,5}X_{NeuAc} B^{2,5}X_{NeuAc} ^{2,5}A_{GlcNAc}Z ^{2,5}A_{GlcNAc}Z
815.4 926.0

Annotations:

^{0,2}X_{GlcNAc}Z ^{0,2}X_{GlcNAc}Z
835.3 825.0

Annotations:

C C
835.9 227.0
857.1 397.0

Annotations:

C^{2,4}X_{NeuAc} C^{2,4}X_{NeuAc}
875.7 169.0

Annotations:

ZZ YZ ZY YZ ZY
876.8 951.0

Annotations:

^{0,2}A_{Man} ^{0,4}A_{Man} ^{1,3}A_{Man} ^{2,4}A_{Man}
897.9 216.0

Annotations:

B
898.3 1196.0

Annotations:

B
900.4 920.0

Annotations:

^{1,4}X_{NeuAc}Y Y^{1,4}X_{NeuAc}
907.3 970.0

Annotations:

C
907.7 541.0

Annotations:

C
908.4 1049.0
908.7 137.0
927.1 508.0

Annotations:

^{1,3}X_{Gal}Z ^{2,4}X_{Gal}Z Z^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Z ^{1,3}X_{Gal}Z ^{2,4}X_{Gal}Z Z^{0,4}X_{Fuc} Z^{1,3}X_{NeuAc} ^{2,5}X_{NeuAc}Z Z^{2,5}X_{NeuAc}
928.5 1415.0

Annotations:

^{2,4}A_{GlcNAc} Y^{3,5}X_{Fuc} ^{0,2}X_{NeuAc}Y Y^{0,2}X_{NeuAc} Y^{3,5}X_{Fuc}
940.3 485.0

Annotations:

B^{0,4}X_{NeuAc} B^{0,4}X_{NeuAc}
942.3 320.0

Annotations:

B^{1,4}X_{NeuAc} B^{1,4}X_{NeuAc} ^{3,5}X_{NeuAc}Z Z^{3,5}X_{NeuAc}
949.3 141.0

Annotations:

Z Z
956.8 138.0

Annotations:

YZ ZY YZ ZY
957.4 2092.0

Annotations:

Y Y
957.9 961.0

Annotations:

Y Y
958.3 433.0

Annotations:

Y Y
958.8 567.0

Annotations:

C^{2,4}X_{NeuAc} C^{2,4}X_{NeuAc} ^{0,2}A_{GlcNAc}
959.5 219.0
961.0 519.0

Annotations:

BZ BZ
962.4 591.0
966.9 327.0

Annotations:

^{1,4}X_{GlcNAc}Y Y^{1,4}X_{Man} ^{1,4}X_{Man}Y Y^{1,4}X_{GlcNAc}
971.2 808.0

Annotations:

Z^{1,5}X_{Fuc} Z^{1,5}X_{Fuc}
977.9 909.0

Annotations:

B^{1,3}X_{NeuAc} Z^{0,2}X_{Fuc} Z^{0,2}X_{Fuc} ^{0,2}X_{GlcNAc}Y Y^{0,2}X_{GlcNAc} B^{1,3}X_{NeuAc}
978.9 508.0

Annotations:

BY BY CZ CZ
985.8 654.0

Annotations:

^{1,5}A_{GlcNAc} Z^{2,5}X_{Fuc} Z^{2,5}X_{Fuc}
986.9 460.0

Annotations:

C^{1,3}X_{NeuAc} C^{1,3}X_{NeuAc} Y^{0,2}X_{Fuc} Y^{0,2}X_{Fuc} ^{2,5}X_{Gal} ^{2,5}X_{Gal}
992.4 220.0

Annotations:

^{1,5}X_{NeuAc}Z ^{1,5}X_{NeuAc}Z Z^{0,3}X_{Fuc} Z^{0,3}X_{Fuc}
998.9 1025.0
1001.5 445.0

Annotations:

^{1,5}X_{NeuAc}Y ^{1,5}X_{NeuAc}Y Y^{0,3}X_{Fuc} Y^{0,3}X_{Fuc}
1006.5 1059.0

Annotations:

^{3,5}X_{GlcNAc}Z Z^{3,5}X_{GlcNAc} ^{0,3}X_{NeuAc}Z ^{0,3}X_{NeuAc}Z
1013.3 131.0
1013.6 183.0
1018.9 510.0
1021.4 578.0

Annotations:

ZZ
1023.3 572.0
1028.5 142.0
1030.0 2232.0

Annotations:

Z Z
1030.4 248.0
1037.4 1095.0
1038.8 1143.0

Annotations:

Y Y
1039.4 1438.0

Annotations:

YZ ZY
1039.8 5422.0

Annotations:

YZ ZY
1046.4 136.0
1059.8 688.0
1060.8 238.0

Annotations:

^{2,4}X_{NeuAc}Y ^{2,4}X_{NeuAc}Y
1065.0 620.0

Annotations:

^{2,5}A_{GlcNAc}Z ^{2,5}A_{GlcNAc}Z ^{2,5}A_{Man}Z ^{2,5}A_{Man}Z
1065.6 358.0

Annotations:

^{2,5}A_{GlcNAc}Z ^{2,5}A_{GlcNAc}Z ^{2,5}A_{Man}Z ^{2,5}A_{Man}Z
1074.0 513.0

Annotations:

^{0,2}X_{NeuAc} ^{0,2}X_{NeuAc}
1074.3 516.0

Annotations:

^{0,2}X_{NeuAc} ^{0,2}X_{NeuAc}
1075.0 605.0

Annotations:

^{1,5}X_{NeuAc} ^{1,5}X_{NeuAc}
1086.4 506.0
1103.3 183.0
1111.4 896.0

Annotations:

Y
1111.9 1253.0

Annotations:

^{1,4}X_{GlcNAc}Z Z^{1,4}X_{GlcNAc}
1113.0 213.0

Annotations:

^{1,5}A_{Man}Y ^{1,5}A_{Man}Y
1113.4 418.0

Annotations:

^{1,5}A_{Man}Y ^{1,5}A_{Man}Y
1116.9 119.0
1125.0 246.0

Annotations:

^{1,5}X_{Fuc}
1125.4 541.0

Annotations:

^{1,5}X_{Fuc}
1131.3 584.0
1133.4 132.0

Annotations:

^{2,4}X_{NeuAc} ^{2,4}X_{NeuAc}
1134.4 138.0
1140.5 550.0

Annotations:

^{2,5}X_{Fuc} ^{0,2}X_{Gal}Y ^{0,2}X_{GlcNAc}Y Y^{0,2}X_{GlcNAc} Y^{0,2}X_{Gal}
1141.4 203.0

Annotations:

BY BY CZ CZ
1145.4 1164.0
1146.0 2782.0
1146.5 562.0
1146.9 1218.0
1147.9 240.0

Annotations:

^{0,3}X_{Fuc}
1151.9 400.0
1154.4 3852.0

Annotations:

^{1,5}A_{GlcNAc}Y ^{1,5}A_{GlcNAc}Y ^{1,3}X_{Fuc} ^{2,4}X_{Fuc}
1154.9 3293.0

Annotations:

^{1,5}A_{GlcNAc}Y ^{1,5}A_{GlcNAc}Y ^{1,3}X_{Fuc} ^{2,4}X_{Fuc}
1155.3 945.0

Annotations:

^{3,5}X_{Fuc}
1156.3 764.0

Annotations:

^{2,5}X_{Gal}Y ^{2,5}X_{GlcNAc}Y Y^{2,5}X_{GlcNAc} Y^{2,5}X_{Gal}
1162.3 215.0

Annotations:

^{0,4}X_{Fuc} ^{1,3}X_{NeuAc} ^{1,3}X_{NeuAc}
1162.6 118.0

Annotations:

^{0,4}X_{Fuc} ^{1,3}X_{NeuAc} ^{1,3}X_{NeuAc}
1166.3 201.0
1167.0 153.0
1167.7 356.0
1168.2 219.0

Annotations:

Z^{3,5}X_{GlcNAc} ^{3,5}X_{GlcNAc}Z
1168.6 250.0

Annotations:

^{3,5}X_{GlcNAc}Z Z^{3,5}X_{GlcNAc}
1174.4 1055.0
1174.9 1589.0
1175.4 13169.0
1175.9 11209.0
1176.5 10203.0
1176.9 5105.0
1177.6 1700.0
1178.0 1470.0
1182.9 601.0

Annotations:

BY BY CZ CZ
1183.4 14636.0

Annotations:

^{2,4}A_{GlcNAc}Z ^{2,4}A_{GlcNAc}Z
1183.9 4936.0
1184.4 11104.0
1260.3 332.0

Annotations:

YY YY YY YY
1261.4 482.0

Annotations:

^{0,2}A_{GlcNAc}Y ^{0,2}A_{GlcNAc}Y
1262.5 245.0
1277.3 695.0
1336.5 498.0
1344.5 306.0

Annotations:

BY BY CZ CZ BY BY CZ CZ
1344.7 115.0

Annotations:

BY BY CZ CZ BY BY CZ CZ
1345.3 194.0
1412.2 260.0
1422.6 213.0

Annotations:

YY YY
1446.0 453.0

Annotations:

YZ ZY
1461.5 112.0

Annotations:

C^{2,5}X_{GlcNAc} Y^{1,4}X_{Fuc} Y^{1,4}X_{Fuc} C^{2,5}X_{GlcNAc}
1462.4 344.0
1463.2 233.0

Annotations:

YY
1502.6 350.0
1506.6 640.0

Annotations:

BY BY CZ CZ
1507.7 314.0

Annotations:

^{1,3}X_{Man}Y ^{1,3}X_{Man}Y Y^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Y Y^{0,4}X_{Fuc} Y^{1,3}X_{NeuAc}
1523.5 327.0
1527.6 351.0
1531.0 122.0
1532.4 643.0
1533.5 1099.0

Annotations:

Z Z
1535.6 382.0

Annotations:

^{0,3}X_{GlcNAc}Y Y^{0,3}X_{GlcNAc} ^{1,4}X_{Gal}Y Y^{1,4}X_{Gal}
1547.7 375.0

Annotations:

BY BY CZ CZ
1548.6 390.0

Annotations:

^{2,4}A_{GlcNAc}Z ^{2,4}A_{GlcNAc}Z
1552.6 1979.0
1553.6 632.0
1610.6 128.0

Annotations:

C^{2,5}X_{NeuAc} C^{2,5}X_{NeuAc} ^{2,5}A_{GlcNAc}Y ^{2,5}A_{GlcNAc}Y
1625.6 1077.0

Annotations:

YY YY
1626.6 1933.0

Annotations:

^{0,2}A_{GlcNAc}Y ^{0,2}A_{GlcNAc}Y
1627.7 552.0
1628.6 2143.0
1629.6 104.0
1668.7 197.0
1690.6 172.0
1691.9 191.0

Annotations:

BZ BZ
1693.8 1112.0

Annotations:

^{2,5}X_{NeuAc}Z Z^{2,5}X_{NeuAc}
1694.5 741.0
1696.9 199.0

Annotations:

B^{2,4}X_{NeuAc} B^{2,4}X_{NeuAc} ^{3,5}X_{GlcNAc}Y ^{3,5}X_{GlcNAc}Y
1697.6 106.0

Annotations:

^{1,5}X_{NeuAc}Y Y^{1,5}X_{NeuAc} Y^{1,4}X_{Gal} ^{1,4}X_{Gal}Y
1709.7 304.0

Annotations:

BY BY CZ CZ
1710.6 551.0

Annotations:

^{2,4}X_{GlcNAc}Y ^{2,4}X_{GlcNAc}Y
1712.6 133.0
1712.9 1234.0
1713.2 444.0

Annotations:

Y Y
1713.7 2837.0

Annotations:

Y Y
1714.5 842.0

Annotations:

C^{2,4}X_{NeuAc} C^{2,4}X_{NeuAc}
1714.7 1437.0

Annotations:

C^{2,4}X_{NeuAc} C^{2,4}X_{NeuAc}
1716.8 581.0
1735.8 235.0
1737.8 545.0
1738.9 248.0
1755.8 292.0

Annotations:

^{0,2}A_{Man}
1756.7 527.0
1771.0 165.0

Annotations:

YY YY
1779.9 137.0

Annotations:

B^{0,2}X_{NeuAc} B^{0,2}X_{NeuAc}
1785.6 180.0

Annotations:

^{1,4}X_{GlcNAc} ^{1,4}X_{GlcNAc}
1786.4 207.0
1787.5 1862.0

Annotations:

YY
1788.0 666.0

Annotations:

YY
1788.8 822.0
1789.4 604.0
1789.6 535.0
1790.8 2293.0
1797.4 308.0

Annotations:

B
1797.8 402.0

Annotations:

B
1798.7 1360.0

Annotations:

^{1,5}X_{Gal}Y ^{1,5}X_{Gal}Y Y^{1,5}X_{Fuc} Y^{1,5}X_{Fuc}
1829.8 146.0
1857.7 107.0

Annotations:

^{2,4}A_{GlcNAc} ^{0,2}X_{NeuAc}Y Y^{0,2}X_{NeuAc}
1858.6 142.0

Annotations:

Y^{3,5}X_{Fuc} Y^{3,5}X_{Fuc}
1874.6 126.0
1883.8 259.0
1896.7 486.0

Annotations:

ZZ ZZ
1897.9 134.0
1898.4 187.0

Annotations:

Z Z
1898.7 335.0

Annotations:

Z Z
1899.5 529.0

Annotations:

B^{2,4}X_{NeuAc} B^{2,4}X_{NeuAc}
1899.9 2410.0

Annotations:

B^{2,4}X_{NeuAc} B^{2,4}X_{NeuAc}
1900.7 199.0
1900.9 485.0
1914.5 173.0

Annotations:

ZY YZ ZY YZ
1916.4 348.0

Annotations:

Y Y
1916.7 2040.0

Annotations:

Y Y
1917.0 739.0

Annotations:

Y Y
1917.8 1556.0

Annotations:

C^{2,4}X_{NeuAc} C^{2,4}X_{NeuAc} ^{0,2}A_{GlcNAc}
1918.4 251.0
1918.8 879.0
1919.6 954.0
1926.6 288.0
1945.7 154.0

Annotations:

^{1,4}X_{NeuAc}Z Z^{1,4}X_{NeuAc}
1946.8 1762.0
1974.5 221.0

Annotations:

C^{1,3}X_{NeuAc} C^{1,3}X_{NeuAc} Y^{0,2}X_{Fuc} Y^{0,2}X_{Fuc} ^{2,5}X_{Gal} ^{2,5}X_{Gal}
1982.4 580.0
1983.7 279.0
2000.9 441.0

Annotations:

B
2001.6 710.0
2001.9 913.0
2018.7 670.0

Annotations:

C
2041.6 311.0
2043.8 235.0
2057.8 437.0
2058.8 198.0
2060.7 5129.0

Annotations:

Z Z
2061.8 1789.0
2062.7 1259.0
2063.8 1944.0
2065.9 135.0
2077.6 429.0
2077.8 1448.0
2078.8 24253.0

Annotations:

Y Y
2079.8 24631.0
2080.5 1658.0
2080.8 8852.0
2081.9 8519.0
2082.7 2222.0
2082.9 3122.0
2122.0 334.0
2122.8 263.0

Annotations:

^{2,4}X_{NeuAc}Y ^{2,4}X_{NeuAc}Y
2123.2 100.0

Annotations:

^{2,4}X_{NeuAc}Y ^{2,4}X_{NeuAc}Y

There are 9 similar spectra:

Id Structure Score

2584

1.00

2583

0.91

2562

0.91

2410

0.85

2409

0.82

2261

0.63

389

0.61

2582

0.61

2561

0.61
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