In-depth N-glycome profiling of paired colorectal cancer and non-tumorigenic tissues reveals cancer-, stage- and EGFR-specific protein N-glycosylation.

PubMed Entry

GlyToucan Accession Number: G22754FQ

Peak Intensity
470.0 110.0

Annotations:

C
653.2 140.0
655.3 393.0

Annotations:

B
817.2 107.0

Annotations:

B B
889.3 152.0

Annotations:

^{0,4}X_{NeuAc}Z Z^{0,4}X_{NeuAc} B^{0,2}X_{NeuAc} B^{0,2}X_{NeuAc}
897.1 197.0

Annotations:

^{0,2}X_{Gal}Z Z^{0,2}X_{Fuc} ^{0,2}X_{Gal}Z Z^{0,2}X_{Fuc} B^{2,5}X_{NeuAc} B^{2,5}X_{NeuAc}
907.2 203.0

Annotations:

C
907.8 335.0

Annotations:

C
908.6 128.0
929.2 105.0

Annotations:

^{3,5}X_{Gal}Y Y^{3,5}X_{Fuc} ^{3,5}X_{Gal}Y Y^{3,5}X_{Fuc} ^{1,5}X_{NeuAc}Y Y^{1,5}X_{NeuAc}
935.8 107.0

Annotations:

^{3,5}A_{GlcNAc} ^{0,4}X_{Gal}Y Y^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Y ^{0,4}X_{Gal}Y Y^{0,4}X_{Fuc} Y^{1,3}X_{NeuAc}
959.0 108.0
980.4 172.0
995.0 157.0

Annotations:

Y^{2,5}X_{Fuc} Y^{2,5}X_{Fuc}
999.4 175.0

Annotations:

B
999.6 149.0

Annotations:

B
999.8 487.0

Annotations:

B
1000.4 297.0

Annotations:

^{0,2}X_{NeuAc}Y Z^{3,5}X_{Fuc} ^{0,2}X_{NeuAc}Y Z^{3,5}X_{Fuc}
1000.7 150.0

Annotations:

^{0,2}X_{NeuAc}Y Z^{3,5}X_{Fuc} ^{0,2}X_{NeuAc}Y Z^{3,5}X_{Fuc}
1054.4 171.0
1074.0 164.0

Annotations:

^{0,2}X_{NeuAc} ^{0,2}X_{NeuAc}
1074.4 269.0

Annotations:

^{1,5}X_{NeuAc} ^{1,5}X_{NeuAc}
1074.9 748.0

Annotations:

^{1,5}X_{NeuAc} ^{1,5}X_{NeuAc}
1111.4 267.0

Annotations:

Y
1112.0 803.0
1112.4 189.0
1113.0 369.0

Annotations:

^{1,5}A_{Man}Y ^{1,5}A_{Man}Y
1117.2 166.0
1117.8 104.0
1145.4 240.0
1154.1 139.0

Annotations:

^{1,5}A_{GlcNAc}Y ^{1,5}A_{GlcNAc}Y ^{1,3}X_{Fuc} ^{2,4}X_{Fuc}
1154.5 474.0

Annotations:

^{1,5}A_{GlcNAc}Y ^{1,5}A_{GlcNAc}Y ^{1,3}X_{Fuc} ^{2,4}X_{Fuc}
1154.9 102.0

Annotations:

^{1,5}A_{GlcNAc}Y ^{1,5}A_{GlcNAc}Y ^{1,3}X_{Fuc} ^{2,4}X_{Fuc}
1155.4 325.0

Annotations:

^{3,5}X_{Fuc}
1164.1 193.0

Annotations:

BZ BZ
1164.3 172.0

Annotations:

BZ BZ
1164.5 258.0

Annotations:

BZ BZ
1165.4 106.0
1167.3 100.0
1174.4 375.0
1175.0 262.0
1175.4 855.0
1175.9 685.0
1176.5 409.0
1177.0 285.0
1183.0 166.0

Annotations:

^{2,4}A_{GlcNAc}Z ^{2,4}A_{GlcNAc}Z
1183.5 1788.0

Annotations:

^{2,4}A_{GlcNAc}Z ^{2,4}A_{GlcNAc}Z
1183.9 2346.0
1184.5 14657.0
1184.9 3399.0
1185.5 351.0
1277.6 104.0
1527.4 182.0
1551.6 153.0

Annotations:

Y Y
1552.6 124.0
1552.7 109.0
1628.7 100.0
1695.7 112.0

Annotations:

Z Z
1709.8 171.0

Annotations:

CZ CZ BY BY
1710.8 273.0

Annotations:

^{2,4}X_{GlcNAc}Y ^{2,4}X_{GlcNAc}Y
1711.7 151.0

Annotations:

^{2,5}X_{NeuAc}Y Y^{2,5}X_{NeuAc}
1713.8 358.0

Annotations:

Y Y
1715.6 171.0
1787.6 122.0

Annotations:

YY
1787.9 160.0

Annotations:

YY
1788.7 228.0
1789.7 179.0
1897.6 121.0
1916.7 168.0

Annotations:

Y Y
1917.6 107.0

Annotations:

C^{2,4}X_{NeuAc} C^{2,4}X_{NeuAc} ^{0,2}A_{GlcNAc}
1917.9 252.0

Annotations:

C^{2,4}X_{NeuAc} C^{2,4}X_{NeuAc} ^{0,2}A_{GlcNAc}
1918.8 191.0
1925.8 126.0
2001.7 124.0
2037.6 128.0
2057.8 116.0
2058.8 188.0
2060.0 142.0
2076.9 155.0
2077.5 165.0
2077.9 180.0
2078.8 4799.0

Annotations:

Y Y
2079.8 4882.0
2080.8 3179.0
2081.9 1393.0
2082.8 346.0
2083.0 473.0

There are 5 similar spectra:

Id Structure Score

2582

1.00

2563

0.61

2584

0.61

2562

0.59

2583

0.59
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