In-depth N-glycome profiling of paired colorectal cancer and non-tumorigenic tissues reveals cancer-, stage- and EGFR-specific protein N-glycosylation.

PubMed Entry

GlyToucan Accession Number: G13249MW

Peak Intensity
424.1 228.0

Annotations:

^{1,3}A_{Man} ^{0,4}A_{Man}Y C^{0,2}X_{Gal}
553.3 158.0

Annotations:

Z
655.3 317.0

Annotations:

B
673.3 103.0

Annotations:

C
804.4 123.0

Annotations:

^{2,5}A_{GlcNAc}Y ^{2,5}A_{GlcNAc}Y
875.9 483.0

Annotations:

YZ ZY
884.3 160.0

Annotations:

Z
886.0 104.0
911.8 193.0

Annotations:

^{1,4}X_{Man}Z Z^{0,3}X_{Fuc} ^{3,5}X_{Gal}Z ^{3,5}X_{GlcNAc}Z Z^{3,5}X_{GlcNAc}
915.9 112.0

Annotations:

B^{2,5}X_{GlcNAc}
926.8 201.0

Annotations:

B^{0,2}X_{NeuAc} ^{1,3}X_{Man}Z Z^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Z Z^{1,5}X_{Fuc}
936.8 137.0

Annotations:

C^{1,5}X_{NeuAc} ^{2,5}X_{NeuAc}Y ^{2,5}X_{NeuAc}Y
944.9 279.0
948.3 178.0

Annotations:

ZZ ZZ
949.5 111.0

Annotations:

Y^{0,3}X_{GlcNAc} Z^{1,4}X_{GlcNAc} B^{3,5}X_{NeuAc} Y^{1,4}X_{Fuc} Y^{0,3}X_{GlcNAc} Y^{0,3}X_{Gal} Y^{1,4}X_{Gal} ^{0,3}X_{GlcNAc} Y^{0,3}X_{Gal} Y^{1,4}X_{Gal}
951.8 177.0

Annotations:

^{1,3}A_{Man}Y ^{2,4}A_{Man}Y ^{3,5}X_{NeuAc}Y ^{3,5}X_{NeuAc}Y
956.9 232.0

Annotations:

YZ ZY YZ ZY
957.8 193.0

Annotations:

Y
965.3 1809.0

Annotations:

CY CY
965.9 1788.0

Annotations:

YY YY
966.4 758.0
966.7 275.0
966.9 156.0

Annotations:

Y^{1,4}X_{GlcNAc}
977.3 265.0

Annotations:

ZZ ZZ
978.5 150.0

Annotations:

C^{2,4}X_{GlcNAc} Y^{0,2}X_{GlcNAc} C^{1,5}X_{Gal} C^{1,5}X_{Gal} ^{0,4}X_{NeuAc}Y ^{0,2}X_{Gal}Y Y^{0,2}X_{Gal} ^{0,4}X_{NeuAc}Y
985.9 136.0

Annotations:

Z
1002.4 187.0

Annotations:

BZ YY
1008.9 167.0

Annotations:

C^{3,5}X_{Gal} C^{3,5}X_{Gal} Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} Y^{1,5}X_{Gal} Y^{1,5}X_{Gal} Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} ^{1,3}X_{Man} ^{0,4}X_{Gal}Y ^{1,3}X_{Gal}Y ^{2,4}X_{Gal}Y Y^{0,4}X_{Gal} Y^{1,3}X_{Gal} Y^{2,4}X_{Gal} C^{0,3}X_{NeuAc}
1009.3 198.0

Annotations:

Y^{0,4}X_{Gal} Y^{1,3}X_{Gal} Y^{2,4}X_{Gal} C^{0,3}X_{NeuAc} C^{3,5}X_{Gal} C^{3,5}X_{Gal} Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} Y^{1,5}X_{Gal} Y^{1,5}X_{Gal} Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} ^{1,3}X_{Man} ^{0,4}X_{Gal}Y ^{1,3}X_{Gal}Y ^{2,4}X_{Gal}Y
1010.3 259.0

Annotations:

Y^{3,5}X_{Fuc} Y^{3,5}X_{Fuc}
1017.8 228.0
1018.4 351.0
1020.5 141.0

Annotations:

BY CZ
1021.5 189.0

Annotations:

^{3,5}X_{GlcNAc}Z ^{3,5}X_{GlcNAc}Z ^{1,5}X_{NeuAc}Z ^{1,5}X_{NeuAc}Z Z^{1,4}X_{Fuc} Z^{0,3}X_{Gal} Z^{1,4}X_{Gal} Z^{0,3}X_{Gal} Z^{1,4}X_{Gal}
1021.8 228.0

Annotations:

^{3,5}X_{GlcNAc}Z ^{3,5}X_{GlcNAc}Z ^{1,5}X_{NeuAc}Z ^{1,5}X_{NeuAc}Z Z^{1,4}X_{Fuc} Z^{0,3}X_{Gal} Z^{1,4}X_{Gal} Z^{0,3}X_{Gal} Z^{1,4}X_{Gal}
1028.5 285.0

Annotations:

^{2,4}X_{GlcNAc}Z ^{2,4}X_{GlcNAc}Z ^{0,2}X_{NeuAc}Z ^{2,5}X_{NeuAc}Z ^{2,5}X_{NeuAc}Z
1028.8 235.0

Annotations:

^{2,4}X_{GlcNAc}Z ^{2,4}X_{GlcNAc}Z ^{0,2}X_{NeuAc}Z ^{2,5}X_{NeuAc}Z ^{2,5}X_{NeuAc}Z
1030.4 219.0

Annotations:

^{3,5}X_{GlcNAc}Y ^{3,5}X_{GlcNAc}Y ^{1,5}X_{NeuAc}Y ^{1,5}X_{NeuAc}Y Y^{1,4}X_{Fuc} Y^{0,3}X_{Gal} Y^{1,4}X_{Gal} Y^{0,3}X_{Gal} Y^{1,4}X_{Gal}
1036.9 511.0

Annotations:

B
1038.4 180.0

Annotations:

Y Y
1038.8 167.0

Annotations:

Y Y
1039.0 336.0

Annotations:

Y Y
1039.4 275.0
1039.9 447.0
1040.4 285.0
1049.3 472.0

Annotations:

ZZ ZZ
1050.0 380.0

Annotations:

YZ ZY
1050.5 198.0

Annotations:

YZ ZY
1050.9 109.0
1053.4 177.0

Annotations:

Y^{0,4}X_{Fuc}
1054.3 172.0

Annotations:

Y^{0,4}X_{Fuc}
1058.4 384.0

Annotations:

YZ ZY YZ ZY
1059.0 897.0

Annotations:

YY
1059.9 186.0
1074.4 264.0

Annotations:

^{1,4}X_{GlcNAc} ^{1,4}X_{GlcNAc}
1074.9 125.0

Annotations:

^{1,4}X_{GlcNAc} ^{1,4}X_{GlcNAc}
1079.8 187.0

Annotations:

^{0,2}X_{Gal}Z Z^{0,2}X_{Fuc} ^{0,4}X_{NeuAc}Z ^{0,2}X_{Gal}Z Z^{0,2}X_{Fuc} ^{2,5}X_{Gal}Z Z^{2,5}X_{Gal}
1089.8 162.0

Annotations:

^{2,4}X_{NeuAc}Y ^{2,4}X_{NeuAc}Y
1093.8 380.0
1099.3 289.0

Annotations:

C^{2,4}X_{NeuAc}
1101.3 131.0

Annotations:

Z^{2,4}X_{Fuc} ^{0,4}X_{Gal}Z ^{1,3}X_{Gal}Z ^{2,4}X_{Gal}Z Z^{1,3}X_{Fuc} Z^{2,4}X_{Fuc} Z^{0,4}X_{Gal} Z^{1,3}X_{Gal} Z^{2,4}X_{Gal} Z^{1,3}X_{Fuc}
1109.4 521.0

Annotations:

^{0,4}X_{Gal}Z ^{1,3}X_{Gal}Z ^{2,4}X_{Gal}Z Z^{0,4}X_{Fuc} ^{0,4}X_{Gal}Z ^{1,3}X_{Gal}Z ^{2,4}X_{Gal}Z Z^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Z ^{1,3}X_{NeuAc}Z
1109.8 602.0

Annotations:

^{1,3}X_{NeuAc}Z ^{1,3}X_{NeuAc}Z ^{0,4}X_{Gal}Z ^{1,3}X_{Gal}Z ^{2,4}X_{Gal}Z Z^{0,4}X_{Fuc} ^{0,4}X_{Gal}Z ^{1,3}X_{Gal}Z ^{2,4}X_{Gal}Z Z^{0,4}X_{Fuc}
1110.4 693.0

Annotations:

^{2,4}X_{GlcNAc} ^{0,4}X_{Gal}Y ^{1,3}X_{Gal}Y ^{2,4}X_{Gal}Y Y^{0,4}X_{Gal} Y^{1,3}X_{Gal} Y^{2,4}X_{Gal} ^{2,4}X_{GlcNAc} Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} ^{0,2}X_{NeuAc} ^{1,4}A_{Man}Y C^{0,3}X_{Gal} C^{1,4}X_{Gal}
1111.0 371.0

Annotations:

^{0,2}X_{NeuAc} ^{3,5}X_{Gal}Y Y^{3,5}X_{Fuc} ^{3,5}X_{Gal}Y Y^{3,5}X_{Fuc}
1111.4 645.0

Annotations:

^{3,5}X_{Gal}Y Y^{3,5}X_{Fuc} ^{3,5}X_{Gal}Y Y^{3,5}X_{Fuc} ^{1,5}X_{NeuAc}
1118.4 284.0

Annotations:

^{2,4}X_{Gal}Y Y^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Y ^{0,4}X_{Gal}Y ^{1,3}X_{Gal}Y ^{2,4}X_{Gal}Y Y^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Y ^{2,5}X_{NeuAc} ^{0,4}X_{Gal}Y ^{1,3}X_{Gal}Y
1119.0 410.0

Annotations:

^{2,5}X_{NeuAc}
1119.5 168.0
1120.0 769.0
1120.3 347.0
1122.4 292.0

Annotations:

B^{0,4}X_{Gal} B^{1,3}X_{Gal} B^{2,4}X_{Gal} Z^{0,2}X_{Gal}
1130.4 127.0
1131.4 384.0

Annotations:

Z Z
1132.0 1084.0
1132.4 397.0
1133.0 417.0
1133.4 220.0

Annotations:

^{3,5}X_{NeuAc}
1133.9 113.0

Annotations:

^{3,5}X_{NeuAc}
1139.4 2497.0

Annotations:

Z
1139.9 1676.0

Annotations:

Z
1140.4 3048.0

Annotations:

Y Y
1140.9 1859.0

Annotations:

Y Y
1141.5 1836.0
1142.0 413.0

Annotations:

Y^{1,5}X_{Fuc}
1142.5 248.0

Annotations:

Y^{1,5}X_{Fuc}
1148.9 337.0

Annotations:

Y
1155.5 120.0

Annotations:

^{0,2}A_{Man}Z
1156.5 149.0

Annotations:

Y^{2,5}X_{Gal} C^{1,3}X_{NeuAc} Y^{0,2}X_{Fuc}
1159.5 117.0
1161.5 258.0

Annotations:

^{0,2}X_{Gal} ^{0,4}X_{NeuAc} ^{0,2}X_{Gal}
1167.0 154.0
1170.0 116.0

Annotations:

Y^{1,4}X_{Fuc} Y^{0,3}X_{Gal} Y^{1,4}X_{Gal}
1170.5 196.0

Annotations:

Y^{1,4}X_{Fuc} Y^{0,3}X_{Gal} Y^{1,4}X_{Gal} ^{2,4}X_{NeuAc}
1171.5 373.0
1173.9 209.0

Annotations:

^{0,2}A_{Man}Y
1180.5 113.0
1182.4 152.0

Annotations:

B
1184.4 143.0

Annotations:

^{0,3}X_{Fuc} ^{3,5}X_{Gal} ^{3,5}X_{Gal} Z^{3,5}X_{Fuc}
1184.9 122.0

Annotations:

^{0,3}X_{Fuc} ^{3,5}X_{Gal} ^{3,5}X_{Gal} Z^{3,5}X_{Fuc}
1191.5 1602.0

Annotations:

^{1,3}X_{Fuc} ^{2,4}X_{Fuc} ^{0,4}X_{Gal} ^{1,3}X_{Gal} ^{2,4}X_{Gal} ^{0,4}X_{Gal} ^{1,3}X_{Gal} ^{2,4}X_{Gal}
1191.9 1601.0

Annotations:

^{2,4}X_{Fuc} ^{0,4}X_{Gal} ^{1,3}X_{Gal} ^{2,4}X_{Gal} ^{0,4}X_{Gal} ^{1,3}X_{Gal} ^{2,4}X_{Gal} ^{1,3}X_{Fuc}
1192.4 485.0

Annotations:

^{3,5}X_{Fuc}
1192.9 314.0

Annotations:

^{3,5}X_{Fuc}
1194.1 136.0
1194.7 157.0
1200.5 3836.0

Annotations:

C
1201.0 1905.0
1201.5 2550.0
1201.8 572.0
1202.1 525.0

Annotations:

Y^{3,5}X_{Fuc}
1202.4 697.0

Annotations:

Y^{3,5}X_{Fuc}
1203.0 110.0
1203.4 202.0
1212.0 207.0
1212.4 673.0
1213.0 198.0
1220.4 115.0
1221.0 354.0

Annotations:

1221.5 1046.0

Annotations:

1242.5 305.0

Annotations:

Z
1243.5 123.0

Annotations:

B^{1,5}X_{GlcNAc}
1261.4 120.0

Annotations:

C^{1,5}X_{GlcNAc}
1369.5 214.0
1566.8 207.0

Annotations:

^{2,4}A_{GlcNAc}Y ^{2,4}A_{GlcNAc}Y
1571.5 178.0
1690.5 172.0

Annotations:

^{0,2}X_{GlcNAc}Z Z^{0,2}X_{GlcNAc} Z^{0,2}X_{GlcNAc} ^{0,2}X_{GlcNAc}Z
1727.6 185.0

Annotations:

CY CY CY CY
1728.7 375.0
1787.5 189.0

Annotations:

Y
1789.7 108.0
1811.6 181.0

Annotations:

B^{1,3}X_{Gal} B^{2,4}X_{Gal} B^{0,4}X_{Gal} B^{1,3}X_{Gal} B^{2,4}X_{Gal} ^{0,2}A_{GlcNAc}Z ^{0,2}A_{GlcNAc}Z B^{0,4}X_{Gal}
1829.7 110.0

Annotations:

^{0,2}A_{GlcNAc}Y ^{0,2}A_{GlcNAc}Y C^{0,4}X_{Gal} C^{1,3}X_{Gal} C^{2,4}X_{Gal} C^{0,4}X_{Gal} C^{1,3}X_{Gal} C^{2,4}X_{Gal} ^{0,2}A_{Man}
1871.6 217.0

Annotations:

B
1872.8 163.0

Annotations:

^{1,3}X_{Man}Y Y^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Y Y^{1,5}X_{Fuc}
1889.7 685.0

Annotations:

C
1890.7 922.0
1891.7 268.0
1892.7 179.0
1915.5 149.0
1972.8 240.0

Annotations:

Z
1974.0 144.0

Annotations:

B^{2,4}X_{NeuAc}
2061.9 177.0

Annotations:

^{3,5}X_{GlcNAc}Y ^{3,5}X_{GlcNAc}Y
2062.8 112.0

Annotations:

Y^{0,3}X_{Gal} Y^{1,4}X_{Gal} ^{1,5}X_{NeuAc}Y ^{1,5}X_{NeuAc}Y Y^{1,4}X_{Fuc} Y^{0,3}X_{Gal} Y^{1,4}X_{Gal}
2064.8 138.0

Annotations:

Y^{2,5}X_{Fuc}
2074.7 278.0

Annotations:

B
2079.7 133.0
2092.8 139.0

Annotations:

C
2149.8 138.0
2152.8 267.0

Annotations:

Y
2153.8 115.0
2155.8 134.0

There are 10 similar spectra:

Id Structure Score

2566

1.00

2412

0.79

2253

0.77

2588

0.77

2567

0.77

394

0.75

2414

0.74

2415

0.72

2413

0.59

2416

0.57
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