In-depth N-glycome profiling of paired colorectal cancer and non-tumorigenic tissues reveals cancer-, stage- and EGFR-specific protein N-glycosylation.

PubMed Entry

GlyToucan Accession Number: G37491LV

Peak Intensity
368.1 219.0

Annotations:

Y
368.3 110.0

Annotations:

Y
389.1 116.0

Annotations:

ZZ
424.1 322.0

Annotations:

^{1,5}A_{Gal} ^{1,3}A_{Man} ^{1,3}A_{Man}Y ^{0,4}A_{Man}Y ^{1,3}A_{Man}Y ^{2,4}A_{Man}Y C^{0,2}X_{Gal} C^{0,2}X_{Gal}
450.3 257.0

Annotations:

B^{2,5}X_{NeuAc}
470.1 136.0

Annotations:

C
528.0 249.0
553.2 174.0

Annotations:

Z
653.3 198.0
655.2 455.0

Annotations:

B
657.4 299.0

Annotations:

^{0,3}A_{Man}Y ^{1,4}A_{Man}Y ^{2,4}A_{GlcNAc}Y C^{0,2}X_{Gal} ^{1,5}A_{Man}Y
670.2 806.0

Annotations:

Z^{0,2}X_{Fuc} Z^{2,5}X_{GlcNAc} ^{2,5}X_{Gal}Z ^{2,5}X_{GlcNAc}Z Z^{2,5}X_{GlcNAc} Z^{2,5}X_{Gal}
671.1 122.0

Annotations:

^{2,5}A_{GlcNAc}Z ^{2,5}A_{Man}Z Y^{0,2}X_{GlcNAc} Y^{0,2}X_{Gal} Y^{0,2}X_{GlcNAc} ^{0,2}X_{Gal}Y ^{0,2}X_{GlcNAc}Y
693.8 270.0

Annotations:

^{1,4}X_{Man}Y ^{3,5}X_{Gal}Y ^{3,5}X_{GlcNAc}Y Y^{3,5}X_{GlcNAc} Y^{0,3}X_{Fuc} Y^{3,5}X_{Gal} Y^{3,5}X_{GlcNAc}
702.8 500.0
715.3 182.0

Annotations:

^{1,3}A_{Man} C^{0,4}X_{NeuAc} C^{1,5}X_{Man} ^{1,5}A_{GlcNAc}Y ^{1,5}X_{GlcNAc}Z Z^{1,5}X_{GlcNAc}
736.5 110.0

Annotations:

^{3,5}A_{GlcNAc}Z B^{3,5}X_{GlcNAc} Z^{1,5}X_{Gal} Z^{1,5}X_{Man} ^{1,5}X_{Gal}Z Z^{1,5}X_{GlcNAc} ^{1,5}X_{GlcNAc}Z
767.5 238.0

Annotations:

C^{2,5}X_{Gal} ^{1,5}X_{NeuAc}Y ^{0,3}X_{GlcNAc}Y Y^{1,4}X_{Fuc} Y^{0,3}X_{GlcNAc} ^{1,4}X_{Man} Y^{1,4}X_{Man} ^{0,3}X_{Gal}Y Y^{1,4}X_{GlcNAc} ^{1,4}X_{GlcNAc}Y Y^{0,3}X_{Gal} Y^{1,4}X_{Gal} C^{0,3}X_{NeuAc}
774.9 212.0

Annotations:

YY
803.3 297.0

Annotations:

Z
803.7 332.0

Annotations:

Z
817.3 960.0

Annotations:

B
819.4 199.0

Annotations:

CY
820.2 103.0
835.3 1596.0

Annotations:

C
836.2 678.0
836.4 277.0
837.3 249.0

Annotations:

B^{3,5}X_{GlcNAc}
838.3 122.0

Annotations:

ZZ
854.4 524.0

Annotations:

B
854.8 661.0

Annotations:

^{2,5}X_{NeuAc}Y ^{0,4}X_{Gal}Z Z^{1,3}X_{GlcNAc} ^{1,3}X_{Man}Y Y^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Y ^{1,5}X_{Gal}Y Y^{1,5}X_{Fuc} C^{1,5}X_{NeuAc}
856.2 109.0

Annotations:

YY
866.8 297.0

Annotations:

ZZ
872.4 127.0
875.4 215.0

Annotations:

ZZ YZ ZY
875.9 232.0

Annotations:

YZ ZY
876.3 342.0

Annotations:

YZ ZY
876.7 464.0

Annotations:

Y
880.2 125.0
884.3 948.0

Annotations:

CY YZ ZY
884.8 2160.0

Annotations:

YZ ZY YY
885.3 253.0

Annotations:

YY
885.9 1188.0
886.1 356.0
895.4 192.0

Annotations:

ZZ
932.7 185.0

Annotations:

^{0,3}X_{GlcNAc}Z
935.5 120.0

Annotations:

Z^{1,3}X_{GlcNAc} Y^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Y Y^{1,5}X_{Fuc}
935.8 108.0

Annotations:

Z^{1,3}X_{GlcNAc} Y^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Y Y^{1,5}X_{Fuc}
937.4 305.0

Annotations:

C^{1,5}X_{Man}
943.3 228.0

Annotations:

C^{1,3}X_{NeuAc} Y^{0,2}X_{Fuc} Y^{2,5}X_{Gal} Y^{2,5}X_{GlcNAc} ^{2,5}X_{Gal} ^{0,3}X_{NeuAc}Y
947.9 406.0

Annotations:

ZZ
949.5 240.0

Annotations:

^{3,5}X_{GlcNAc}Y ^{1,5}X_{NeuAc}Y Y^{1,4}X_{Fuc} Y^{0,3}X_{Gal} Y^{1,4}X_{Gal} Y^{0,3}X_{GlcNAc} ^{0,3}X_{Gal}
952.9 162.0
956.3 498.0

Annotations:

B
958.3 465.0

Annotations:

Y
962.3 112.0
968.2 116.0

Annotations:

ZZ
969.5 216.0

Annotations:

^{0,4}X_{NeuAc}Z Z^{0,2}X_{Gal}
977.4 420.0

Annotations:

YZ ZY
977.8 867.0

Annotations:

YZ ZY
978.3 275.0

Annotations:

Z^{0,2}X_{Fuc} Z^{2,5}X_{Gal}
993.0 275.0

Annotations:

^{1,4}X_{NeuAc}Z ^{0,2}A_{Man}Z ^{0,2}A_{GlcNAc}Z B^{1,3}X_{Man} ^{1,4}X_{GlcNAc}Z Z^{0,3}X_{Fuc} Z^{3,5}X_{Gal}
995.4 241.0

Annotations:

^{2,5}A_{GlcNAc}Y ^{2,5}A_{Man}Y
996.1 176.0
1021.3 179.0

Annotations:

Z^{3,5}X_{Fuc} ^{3,5}X_{Gal}Z ^{3,5}X_{GlcNAc}Z
1026.3 200.0
1028.3 319.0

Annotations:

^{0,4}X_{Gal}Z ^{1,3}X_{Gal}Z ^{2,4}X_{Gal}Z ^{0,4}X_{GlcNAc}Z ^{2,4}X_{GlcNAc}Z Z^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Z
1028.9 202.0

Annotations:

Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} ^{2,4}X_{GlcNAc} ^{0,4}X_{GlcNAc}Y ^{2,4}X_{GlcNAc}Y
1029.8 124.0

Annotations:

Z
1030.7 202.0

Annotations:

^{3,5}X_{Gal}Y Y^{3,5}X_{Fuc} ^{3,5}X_{GlcNAc}Y ^{1,5}X_{NeuAc}
1037.3 217.0

Annotations:

^{0,4}X_{Gal}Y ^{2,4}X_{Gal}Y Y^{0,4}X_{Fuc} ^{0,4}X_{GlcNAc}Y ^{2,4}X_{GlcNAc}Y ^{1,3}X_{NeuAc}Y ^{1,3}X_{Gal}Y
1037.8 215.0

Annotations:

^{0,4}X_{Gal}Y ^{1,3}X_{Gal}Y ^{2,4}X_{Gal}Y Y^{0,4}X_{Fuc} ^{0,4}X_{GlcNAc}Y ^{2,4}X_{GlcNAc}Y ^{1,3}X_{NeuAc}Y ^{2,5}X_{NeuAc}
1038.3 402.0

Annotations:

^{2,5}X_{NeuAc} ^{1,3}X_{Man}Y Y^{1,3}X_{Man}
1038.9 264.0

Annotations:

Y
1039.8 209.0
1050.3 186.0

Annotations:

Z
1050.9 540.0
1052.0 310.0
1052.8 142.0

Annotations:

^{1,5}X_{GlcNAc} ^{3,5}X_{NeuAc}
1058.5 1516.0

Annotations:

Z
1059.0 1763.0

Annotations:

Y
1059.4 1048.0

Annotations:

Y
1059.9 1686.0
1060.4 962.0
1060.8 137.0
1067.5 127.0

Annotations:

Y
1067.9 532.0
1081.4 278.0

Annotations:

B^{1,5}X_{GlcNAc} ^{1,5}X_{Fuc}
1082.2 142.0
1089.9 298.0

Annotations:

^{1,3}X_{GlcNAc} ^{2,4}X_{NeuAc}
1090.4 282.0
1105.9 188.0
1109.9 236.0

Annotations:

^{1,4}A_{Man}
1110.5 621.0

Annotations:

^{1,4}A_{Man} ^{0,4}X_{Gal} ^{1,3}X_{Gal} ^{2,4}X_{Gal} ^{0,4}X_{GlcNAc} ^{2,4}X_{GlcNAc} ^{1,3}X_{Fuc} ^{2,4}X_{Fuc}
1111.0 383.0

Annotations:

^{3,5}X_{Fuc}
1111.5 780.0

Annotations:

^{3,5}X_{Fuc}
1114.1 169.0
1119.4 1398.0
1120.0 1335.0
1120.4 559.0
1120.9 217.0
1131.5 101.0
1132.6 199.0
1155.5 110.0

Annotations:

^{0,2}A_{GlcNAc}Z
1224.3 369.0

Annotations:

ZZ ZZ
1268.2 224.0

Annotations:

^{2,5}A_{GlcNAc}Z ^{2,5}A_{Man}Z
1286.6 180.0

Annotations:

^{2,5}A_{GlcNAc}Y ^{2,5}A_{Man}Y
1369.4 158.0

Annotations:

^{1,4}A_{GlcNAc}Z B^{0,3}X_{GlcNAc}
1408.3 215.0
1421.8 137.0
1441.5 261.0

Annotations:

BZ
1460.6 114.0

Annotations:

^{2,4}A_{GlcNAc}Z
1463.6 171.0

Annotations:

Y
1465.5 123.0
1466.7 208.0
1507.7 121.0

Annotations:

^{1,5}X_{GlcNAc}Y Y^{1,5}X_{Fuc}
1524.8 113.0

Annotations:

CY
1546.5 108.0

Annotations:

Y^{0,2}X_{GlcNAc} ^{0,2}X_{GlcNAc}Y
1548.6 117.0

Annotations:

^{2,4}A_{GlcNAc}Z
1549.7 523.0

Annotations:

^{1,4}A_{GlcNAc}Y C^{0,3}X_{Gal} ^{2,5}X_{NeuAc}Y Z^{3,5}X_{Fuc}
1552.7 141.0

Annotations:

C^{3,5}X_{NeuAc} C^{1,5}X_{GlcNAc}
1565.5 243.0

Annotations:

CY CY
1567.4 134.0

Annotations:

Y^{3,5}X_{Fuc}
1567.7 146.0

Annotations:

Y^{3,5}X_{Fuc}
1572.5 118.0

Annotations:

ZZ
1592.4 173.0

Annotations:

^{2,5}A_{GlcNAc}Z Y^{3,5}X_{GlcNAc} ^{0,3}X_{GlcNAc}Y ^{3,5}X_{GlcNAc}Y
1621.6 220.0

Annotations:

BY CZ
1649.6 357.0

Annotations:

^{0,2}A_{GlcNAc}Z B^{0,4}X_{Gal} B^{1,3}X_{Gal} B^{2,4}X_{Gal} B^{0,4}X_{GlcNAc} B^{2,4}X_{GlcNAc} ^{0,2}X_{Gal}Z
1677.8 168.0

Annotations:

ZZ
1709.6 161.0

Annotations:

B
1710.7 230.0

Annotations:

^{1,3}X_{Man}Y Y^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Y ^{1,5}X_{Gal}Y Y^{1,5}X_{Fuc}
1716.6 172.0
1727.5 507.0

Annotations:

C
1727.8 501.0

Annotations:

C
1728.6 616.0
1729.8 364.0
1730.7 117.0
1733.7 184.0
1737.7 132.0

Annotations:

B^{1,5}X_{GlcNAc} B^{3,5}X_{NeuAc}
1752.6 433.0

Annotations:

ZY YZ
1754.8 101.0

Annotations:

Y
1769.3 118.0

Annotations:

YZ ZY
1769.8 232.0

Annotations:

YZ ZY
1771.0 458.0

Annotations:

YY
1815.9 181.0

Annotations:

C^{1,4}X_{NeuAc} Y^{1,5}X_{GlcNAc} ^{1,3}X_{GlcNAc}Y ^{2,4}X_{NeuAc}Y
1828.6 195.0

Annotations:

Y
1828.8 616.0

Annotations:

Y
1829.8 369.0

Annotations:

C^{1,3}X_{GlcNAc} C^{2,4}X_{NeuAc} ^{0,2}A_{GlcNAc}
1830.8 115.0
1831.8 193.0
1837.7 141.0
1845.7 138.0
1856.8 137.0

Annotations:

C^{3,5}X_{Gal} C^{3,5}X_{GlcNAc} Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} Y^{1,5}X_{Gal} ^{1,3}X_{Man} ^{0,4}X_{GlcNAc}Y ^{2,4}X_{GlcNAc}Y Y^{2,4}X_{GlcNAc} ^{1,5}X_{Gal}
1890.8 443.0
1894.7 261.0
1895.0 143.0
1912.7 507.0

Annotations:

B
1913.8 387.0

Annotations:

^{2,4}X_{GlcNAc}Y
1914.4 277.0

Annotations:

YZ ZY
1914.7 122.0

Annotations:

YZ ZY
1915.8 147.0
1917.9 217.0
1926.5 200.0

Annotations:

^{0,3}X_{NeuAc}Z ^{1,5}X_{GlcNAc}Z Z^{1,5}X_{Gal} ^{3,5}X_{NeuAc}Z
1931.9 693.0
1948.8 100.0
1990.8 461.0

Annotations:

Y
1991.9 131.0
1992.7 292.0
1993.9 120.0

There are 6 similar spectra:

Id Structure Score

386

0.69

2274

0.69

2247

0.68

2395

0.64

2396

0.59

2275

0.54
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