In-depth N-glycome profiling of paired colorectal cancer and non-tumorigenic tissues reveals cancer-, stage- and EGFR-specific protein N-glycosylation.

PubMed Entry

GlyToucan Accession Number: G28493ST

Peak Intensity
653.0 203.0
655.3 601.0

Annotations:

B
657.3 133.0

Annotations:

^{1,5}A_{GlcNAc}Y ^{1,5}A_{Man}Z C^{2,5}X_{GlcNAc} Y^{1,4}X_{Fuc} ^{1,4}X_{Fuc}Y ^{0,3}X_{Gal}Y ^{1,4}X_{Gal}Y Y^{1,4}X_{Man}
673.1 353.0

Annotations:

C
689.3 102.0

Annotations:

CY
727.1 109.0
774.3 115.0

Annotations:

Z
774.9 134.0

Annotations:

Z Y
775.2 227.0

Annotations:

Z Y
817.4 312.0

Annotations:

B
826.3 154.0

Annotations:

Y^{1,5}X_{Gal} Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} ^{1,3}X_{Man} ^{1,5}X_{Gal}Y Y^{1,5}X_{Fuc} ^{1,5}X_{Fuc}Y C^{1,5}X_{NeuAc}
827.8 103.0
828.5 179.0
835.3 300.0

Annotations:

C
836.1 135.0
855.9 193.0

Annotations:

Y
856.3 352.0

Annotations:

Y
856.4 375.0

Annotations:

Y
856.7 380.0

Annotations:

Y
857.3 128.0
872.2 354.0
892.3 198.0

Annotations:

C^{2,5}X_{Fuc}
898.3 137.0

Annotations:

B^{3,5}X_{Fuc} Z^{1,5}X_{Fuc} ^{1,5}X_{Fuc}Z
907.3 198.0

Annotations:

^{1,5}X_{Fuc}Y Y^{1,5}X_{Fuc} C^{3,5}X_{Fuc} ^{0,3}A_{Man}
908.3 360.0

Annotations:

^{3,5}A_{GlcNAc}Y
908.9 161.0
911.5 103.0

Annotations:

Z^{0,2}X_{NeuAc}
920.3 103.0

Annotations:

^{1,5}X_{NeuAc}Z Z^{1,5}X_{NeuAc} ^{2,5}A_{GlcNAc}Z ^{2,5}A_{Man}Z ^{0,3}X_{Fuc}Z ^{3,5}X_{Gal}Z Z^{0,3}X_{Fuc} Y^{0,2}X_{NeuAc}
924.8 118.0

Annotations:

^{0,3}A_{GlcNAc}Y C^{1,4}X_{Man}
929.8 154.0

Annotations:

^{1,5}X_{NeuAc}Y Y^{1,5}X_{NeuAc} Y^{0,3}X_{Fuc} ^{3,5}X_{Gal} ^{0,3}X_{Fuc}Y ^{3,5}X_{Gal}Y
939.8 296.0

Annotations:

ZZ ZZ
950.4 129.0

Annotations:

^{1,5}A_{Man}Z
953.9 156.0

Annotations:

^{0,2}A_{GlcNAc}Y C^{1,3}X_{Man} ^{0,2}A_{Man}Y
957.9 106.0

Annotations:

YY YY
958.3 121.0

Annotations:

YY YY
958.4 107.0
959.3 126.0
959.9 102.0

Annotations:

Z^{0,2}X_{GlcNAc}
961.3 192.0

Annotations:

BZ
965.9 116.0

Annotations:

Y
977.9 397.0

Annotations:

BZ
980.1 343.0

Annotations:

^{1,5}X_{Fuc}Y Y^{1,5}X_{Fuc} Y^{2,4}X_{NeuAc}
998.9 451.0
999.8 470.0

Annotations:

Z^{1,3}X_{Fuc} Z^{2,4}X_{Fuc} ^{0,4}X_{Gal}Z ^{1,3}X_{Gal}Z ^{2,4}X_{Gal}Z Z^{0,4}X_{Fuc} ^{1,3}X_{Fuc}Z ^{2,4}X_{Fuc}Z Z^{0,4}X_{Gal} Z^{1,3}X_{Gal} Z^{2,4}X_{Gal} Z^{1,3}X_{NeuAc} ^{0,4}X_{Fuc}Z
1000.3 646.0

Annotations:

Z^{1,3}X_{NeuAc} Z^{1,3}X_{Fuc} Z^{2,4}X_{Fuc} ^{0,4}X_{Gal}Z ^{1,3}X_{Gal}Z ^{2,4}X_{Gal}Z Z^{0,4}X_{Fuc} ^{1,3}X_{Fuc}Z ^{2,4}X_{Fuc}Z Z^{0,4}X_{Gal} Z^{1,3}X_{Gal} Z^{2,4}X_{Gal} ^{0,4}X_{Fuc}Z
1000.8 672.0

Annotations:

^{3,5}X_{Fuc}Z Z^{3,5}X_{Fuc} Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} ^{1,3}X_{Fuc}Y ^{2,4}X_{Fuc}Y
1001.4 801.0

Annotations:

^{0,2}X_{NeuAc} ^{0,3}X_{Fuc}Y Y^{0,3}X_{Fuc} ^{3,5}X_{Gal}Y Y^{3,5}X_{Gal} Y^{3,5}X_{Fuc} ^{3,5}X_{Fuc}Y
1001.9 440.0

Annotations:

^{0,3}X_{Fuc}Y Y^{0,3}X_{Fuc} ^{3,5}X_{Gal}Y Y^{3,5}X_{Gal} Y^{3,5}X_{Fuc} ^{3,5}X_{Fuc}Y ^{1,5}X_{NeuAc}
1002.9 278.0
1008.9 431.0

Annotations:

^{2,4}X_{Fuc}Y Y^{0,4}X_{Gal} Y^{1,3}X_{Gal} Y^{2,4}X_{Gal} Y^{0,4}X_{Fuc} Y^{1,3}X_{NeuAc} ^{0,4}X_{Fuc}Y ^{2,5}X_{NeuAc} ^{1,5}A_{GlcNAc}Y Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} ^{0,4}X_{Gal}Y ^{1,3}X_{Gal}Y ^{2,4}X_{Gal}Y ^{1,3}X_{Fuc}Y
1009.5 171.0

Annotations:

^{2,5}X_{NeuAc} ^{1,5}A_{GlcNAc}Y ^{3,5}X_{Fuc}Y Y^{3,5}X_{Fuc}
1009.9 181.0

Annotations:

^{3,5}X_{Fuc}Y Y^{3,5}X_{Fuc}
1011.2 399.0
1021.8 125.0

Annotations:

Z
1030.4 283.0

Annotations:

Y
1030.9 472.0

Annotations:

Y
1037.0 163.0

Annotations:

BY CZ
1038.9 258.0

Annotations:

Y Y
1039.5 130.0

Annotations:

YZ ZY
1045.9 339.0
1048.9 128.0
1051.2 198.0

Annotations:

^{0,3}A_{GlcNAc}Z B^{1,4}X_{Man}
1052.0 218.0

Annotations:

^{0,4}X_{NeuAc} ^{0,2}X_{Gal} ^{3,5}A_{GlcNAc}Z
1060.4 253.0
1075.9 148.0
1080.5 252.0

Annotations:

YZ ZY
1080.9 574.0

Annotations:

YZ ZY
1081.9 789.0

Annotations:

^{1,3}X_{Fuc} ^{2,4}X_{Fuc} ^{1,3}X_{Fuc} ^{2,4}X_{Fuc} ^{0,4}X_{Gal} ^{1,3}X_{Gal} ^{2,4}X_{Gal} ^{2,5}A_{GlcNAc}Z
1082.3 137.0

Annotations:

^{1,3}X_{Fuc} ^{2,4}X_{Fuc} ^{1,3}X_{Fuc} ^{2,4}X_{Fuc} ^{0,4}X_{Gal} ^{1,3}X_{Gal} ^{2,4}X_{Gal} ^{2,5}A_{GlcNAc}Z
1082.7 212.0

Annotations:

^{2,5}A_{GlcNAc}Z ^{3,5}X_{Fuc} ^{3,5}X_{Fuc}
1083.0 230.0

Annotations:

^{3,5}X_{Fuc} ^{3,5}X_{Fuc} ^{2,5}A_{GlcNAc}Y ^{2,5}A_{Man}Y C^{1,5}X_{Man}
1089.0 134.0
1089.5 101.0

Annotations:

^{0,4}X_{Fuc} ^{1,3}X_{NeuAc} ^{0,4}X_{Fuc}
1090.8 121.0
1092.4 191.0

Annotations:

^{1,4}A_{GlcNAc}Z
1101.3 521.0
1101.9 596.0
1102.4 1330.0
1103.0 329.0
1110.4 162.0

Annotations:

^{1,4}A_{GlcNAc}Y
1110.9 151.0
1111.4 858.0

Annotations:

Z^{1,4}X_{GlcNAc}
1142.3 140.0
1258.6 137.0
1275.5 208.0

Annotations:

C^{2,5}X_{Gal}
1277.5 267.0
1368.5 219.0
1386.5 109.0

Annotations:

ZZ ZZ ZZ
1402.6 278.0

Annotations:

BY CZ
1405.4 130.0

Annotations:

YY
1407.4 207.0
1420.6 100.0

Annotations:

CY
1441.7 103.0
1479.7 271.0

Annotations:

C^{0,3}X_{NeuAc}
1506.5 247.0

Annotations:

BY CZ
1508.5 189.0

Annotations:

CY
1547.8 209.0

Annotations:

^{2,4}X_{GlcNAc}Z Z^{2,4}X_{GlcNAc}
1548.9 139.0

Annotations:

^{2,4}A_{GlcNAc}Z B^{0,2}X_{Fuc} B^{2,5}X_{Gal}
1567.7 269.0

Annotations:

YY
1568.5 193.0

Annotations:

Y
1571.5 128.0
1610.4 119.0

Annotations:

^{2,5}A_{GlcNAc}Y C^{0,4}X_{Gal} C^{1,3}X_{Gal} C^{2,4}X_{Gal} ^{0,2}A_{GlcNAc}Y C^{1,3}X_{Fuc} C^{2,4}X_{Fuc} ^{0,2}A_{Man}
1624.6 137.0

Annotations:

^{1,5}A_{Man}
1629.7 162.0
1641.7 604.0
1642.5 118.0
1671.6 199.0
1694.8 141.0
1695.7 164.0

Annotations:

Z
1709.4 192.0

Annotations:

BY CZ
1709.7 218.0

Annotations:

BY CZ
1710.8 145.0
1712.7 250.0

Annotations:

^{2,4}A_{GlcNAc}
1713.7 113.0

Annotations:

Y
1715.7 138.0
1750.7 170.0
1751.6 180.0

Annotations:

ZZ ZZ
1752.6 483.0
1753.9 174.0

Annotations:

Z
1770.6 437.0
1772.7 263.0

Annotations:

C^{2,4}X_{NeuAc} ^{0,2}A_{GlcNAc}
1773.7 334.0
1873.8 153.0

Annotations:

C
1874.6 145.0
1890.9 185.0
1891.8 178.0
1899.7 179.0
1913.6 148.0
1914.6 148.0

Annotations:

YZ ZY
1914.8 108.0

Annotations:

YZ ZY
1915.6 215.0

Annotations:

Z
1930.7 465.0
1931.5 266.0
1931.8 105.0
1932.8 7902.0

Annotations:

YY
1933.8 7100.0

Annotations:

Y
1934.8 3408.0
1935.8 950.0
1936.7 615.0
1937.9 107.0
1938.1 227.0
1938.7 309.0
1938.8 274.0
1958.6 135.0

Annotations:

^{0,4}X_{NeuAc}Y Y^{0,4}X_{NeuAc} ^{0,2}X_{Gal}Y Y^{0,2}X_{Gal} Y^{0,2}X_{Fuc} ^{0,2}X_{Fuc}Y
1972.0 128.0
2107.5 134.0

There are 12 similar spectra:

Id Structure Score

2258

0.96

569

0.96

593

0.95

2386

0.94

2251

0.90

2387

0.89

2552

0.83

378

0.79

2390

0.78

616

0.68

2392

0.61

3646

0.60
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