Cystic fibrosis and bacterial colonization define the sputum N-glycosylation phenotype

PubMed Entry

GlyToucan Accession Number: G09675DY

Peak Intensity
306.4 1607.0

Annotations:

C^{0,2}X_{NeuAc} C^{0,2}X_{NeuAc}
337.0 288.0

Annotations:

B^{1,4}X_{NeuAc}
368.4 241.0
381.0 210.0
382.0 318.0

Annotations:

CY CY CY
391.2 137.0
407.1 282.0

Annotations:

Z
408.3 500.0

Annotations:

B B
424.2 562.0

Annotations:

^{1,5}A_{Gal} ^{1,3}A_{Man}Y ^{0,4}A_{Man}Y ^{2,4}A_{Man}Y ^{1,3}A_{Man}Y C^{0,2}X_{Gal} C^{0,2}X_{Gal}
425.1 383.0

Annotations:

Y
433.9 135.0

Annotations:

B^{0,2}X_{NeuAc}
459.6 695.0
470.2 267.0

Annotations:

C
472.3 440.0
512.0 1336.0

Annotations:

^{0,3}X_{Gal}Y Y^{1,4}X_{Man} ^{0,3}X_{GlcNAc}Y Y^{0,3}X_{GlcNAc} ^{1,4}X_{Man}Y Y^{0,3}X_{Gal} ^{2,4}A_{GlcNAc} C^{1,5}X_{Man} C^{1,5}X_{Man}
526.3 143.0

Annotations:

BY BY CZ CZ
546.2 664.0
554.4 336.0

Annotations:

B^{2,4}X_{NeuAc} ^{1,4}A_{GlcNAc}Y ^{1,4}A_{GlcNAc}Y
593.2 250.0

Annotations:

Y^{1,4}X_{Man} C^{1,5}X_{GlcNAc} C^{1,5}X_{GlcNAc} ^{0,3}X_{Gal}Y Y^{1,4}X_{GlcNAc} ^{1,4}X_{GlcNAc}Y Y^{0,3}X_{Gal} ^{1,4}X_{Man}Y
605.2 541.0
618.3 233.0
619.2 339.0

Annotations:

Z^{2,4}X_{GlcNAc} ^{2,4}X_{GlcNAc}Z
653.3 203.0
655.2 5866.0

Annotations:

B
656.0 399.0
656.2 435.0
656.5 342.0
657.5 495.0

Annotations:

^{1,5}A_{GlcNAc}Y ^{1,5}A_{GlcNAc}Y ^{1,5}A_{Man}Y ^{1,5}A_{Man}Y
671.5 670.0

Annotations:

BY BY CZ CZ BY BY CZ CZ
688.2 384.0

Annotations:

^{0,3}X_{NeuAc}Y Y^{0,3}X_{NeuAc}
691.0 580.0
701.8 948.0

Annotations:

Y Y
702.3 1300.0

Annotations:

Y Y
703.3 698.0
706.3 209.0
775.2 368.0

Annotations:

^{1,5}X_{NeuAc}Y Y^{1,5}X_{NeuAc} Y^{0,3}X_{Gal} ^{0,3}X_{Gal}Y
775.5 706.0

Annotations:

^{1,5}X_{NeuAc}Y Y^{1,5}X_{NeuAc} Y^{0,3}X_{Gal} ^{0,3}X_{Gal}Y
776.3 140.0
782.9 892.0

Annotations:

Y Y
783.4 788.0

Annotations:

Y Y
796.3 461.0

Annotations:

C^{1,5}X_{Gal} C^{1,5}X_{Gal} C^{0,2}X_{NeuAc} C^{0,2}X_{NeuAc}
800.0 446.0
817.2 3092.0

Annotations:

B B
818.0 845.0

Annotations:

^{1,4}A_{GlcNAc}Y ^{1,4}A_{GlcNAc}Y C^{0,3}X_{Gal} C^{0,3}X_{Gal} ^{1,4}X_{NeuAc}Z Z^{1,4}X_{NeuAc}
818.3 836.0

Annotations:

^{1,4}A_{GlcNAc}Y ^{1,4}A_{GlcNAc}Y C^{0,3}X_{Gal} C^{0,3}X_{Gal} ^{1,4}X_{NeuAc}Z Z^{1,4}X_{NeuAc}
820.2 390.0

Annotations:

YY
826.4 812.0

Annotations:

C^{3,5}X_{Gal} C^{3,5}X_{Gal}
835.3 2321.0

Annotations:

C C
836.1 490.0
836.4 266.0
845.4 418.0

Annotations:

BZ BZ
856.2 823.0

Annotations:

^{1,5}X_{NeuAc}Y Y^{1,5}X_{NeuAc}
856.4 795.0

Annotations:

^{1,5}X_{NeuAc}Y Y^{1,5}X_{NeuAc} C^{2,4}X_{NeuAc} C^{2,4}X_{NeuAc}
857.5 387.0
858.4 401.0
873.5 261.0
876.3 311.0

Annotations:

Z Z
877.3 497.0

Annotations:

^{0,2}A_{Man} ^{0,4}A_{Man} ^{1,3}A_{Man} ^{2,4}A_{Man}
885.3 303.0

Annotations:

Y Y
889.3 441.0

Annotations:

B^{0,2}X_{NeuAc} B^{0,2}X_{NeuAc}
889.8 615.0

Annotations:

B^{1,5}X_{NeuAc} B^{1,5}X_{NeuAc}
890.5 1334.0

Annotations:

B^{1,5}X_{NeuAc} B^{1,5}X_{NeuAc}
898.3 479.0

Annotations:

B
899.3 196.0

Annotations:

^{1,5}X_{Gal} ^{1,5}X_{Gal} C^{1,5}X_{NeuAc} C^{1,5}X_{NeuAc} ^{1,4}X_{NeuAc}Z Z^{1,4}X_{NeuAc}
899.8 319.0

Annotations:

^{1,4}X_{NeuAc}Z Z^{1,4}X_{NeuAc}
906.0 274.0

Annotations:

^{0,2}X_{Gal} ^{0,4}X_{NeuAc}Y Y^{0,4}X_{NeuAc} ^{0,2}X_{Gal} C^{2,5}X_{NeuAc} C^{2,5}X_{NeuAc} ^{2,4}X_{NeuAc}Z Z^{2,4}X_{NeuAc}
906.5 873.0

Annotations:

C^{2,5}X_{NeuAc} C^{2,5}X_{NeuAc} ^{2,4}X_{NeuAc}Z Z^{2,4}X_{NeuAc}
906.8 841.0

Annotations:

^{2,4}X_{NeuAc}Z Z^{2,4}X_{NeuAc}
907.4 289.0

Annotations:

C
909.3 582.0
909.6 173.0
910.2 619.0
911.5 368.0

Annotations:

YY
915.9 434.0

Annotations:

ZZ ZZ
918.5 328.0
924.9 230.0
925.9 421.0
936.5 144.0
941.3 166.0
943.3 921.0

Annotations:

^{0,3}A_{GlcNAc}
943.6 714.0

Annotations:

^{0,3}A_{GlcNAc} ^{1,3}X_{NeuAc}Y Y^{1,3}X_{NeuAc}
949.0 883.0

Annotations:

C^{0,4}X_{NeuAc} C^{0,4}X_{NeuAc} B^{2,4}X_{NeuAc} B^{2,4}X_{NeuAc}
950.7 564.0

Annotations:

^{2,5}A_{GlcNAc}
958.5 180.0

Annotations:

C^{2,4}X_{NeuAc} C^{2,4}X_{NeuAc} ^{0,2}A_{GlcNAc}
959.0 439.0
961.1 431.0

Annotations:

BZ BZ
961.5 718.0

Annotations:

BZ BZ
962.2 197.0

Annotations:

^{1,5}X_{Gal}Z Z^{1,5}X_{Man} ^{1,5}X_{Man}Z Z^{1,5}X_{Gal}
963.4 533.0

Annotations:

^{1,4}A_{GlcNAc}
970.9 288.0
979.4 878.0

Annotations:

BY BY CZ CZ
980.6 690.0

Annotations:

^{1,5}X_{Gal}Y Y^{1,5}X_{Man} ^{1,5}X_{Man}Y Y^{1,5}X_{Gal}
988.5 309.0
991.2 191.0
997.7 931.0

Annotations:

CY CY
999.9 6148.0

Annotations:

B
1000.4 6669.0

Annotations:

^{0,2}X_{NeuAc} ^{0,2}X_{NeuAc}
1000.9 13366.0

Annotations:

^{0,2}X_{NeuAc} ^{0,2}X_{NeuAc}
1001.4 12430.0

Annotations:

^{1,5}X_{NeuAc} ^{1,5}X_{NeuAc}
1001.9 3066.0

Annotations:

^{1,5}X_{NeuAc} ^{1,5}X_{NeuAc}
1002.4 2627.0
1003.0 209.0
1011.4 901.0
1019.6 793.0
1020.6 232.0
1027.2 1143.0
1030.5 257.0
1036.5 2402.0

Annotations:

^{0,4}X_{Gal}Z Z^{1,3}X_{Man} ^{2,4}X_{GlcNAc}Z Z^{2,4}X_{GlcNAc} ^{1,3}X_{Man}Z Z^{0,4}X_{Gal}
1037.4 1132.0
1049.5 163.0
1051.0 1179.0

Annotations:

^{0,3}A_{GlcNAc}Z ^{0,3}A_{GlcNAc}Z B^{1,4}X_{Man} B^{1,4}X_{Man} ^{0,4}X_{NeuAc} ^{0,4}X_{NeuAc}
1053.2 287.0

Annotations:

^{3,5}A_{GlcNAc}Y ^{3,5}A_{GlcNAc}Y
1054.3 281.0

Annotations:

^{1,3}X_{Man}Y Y^{0,4}X_{Gal} ^{1,4}X_{NeuAc} ^{1,4}X_{NeuAc} ^{0,4}X_{Gal}Y Y^{1,3}X_{Man} ^{2,4}X_{GlcNAc}Y Y^{2,4}X_{GlcNAc}
1055.7 319.0
1057.4 986.0
1059.5 395.0
1077.5 715.0
1081.4 680.0

Annotations:

B^{1,3}X_{Man} ^{0,2}A_{Man}Z ^{0,2}A_{GlcNAc}Z ^{0,2}A_{GlcNAc}Z B^{1,3}X_{Man} ^{0,2}A_{Man}Z
1082.0 3496.0
1082.4 1814.0
1090.4 820.0
1090.8 1093.0
1091.4 1221.0
1093.3 563.0
1094.5 245.0
1096.7 427.0

Annotations:

YZ ZY YZ ZY YZ ZY YZ ZY
1098.7 363.0
1102.4 5374.0
1103.0 3641.0
1103.5 3010.0
1104.0 846.0
1122.3 138.0
1159.6 359.0

Annotations:

CY CY
1175.3 796.0
1182.5 605.0

Annotations:

BY BY CZ CZ
1184.3 244.0

Annotations:

^{0,2}X_{NeuAc}Y ^{3,5}X_{Gal}Z Z^{3,5}X_{Gal} Y^{0,2}X_{NeuAc}
1195.4 602.0

Annotations:

Z^{2,5}X_{GlcNAc} ^{2,5}X_{GlcNAc}Z
1216.4 327.0

Annotations:

^{1,3}X_{Man}Y Y^{1,3}X_{Man} ^{0,4}X_{Gal}Y Y^{0,4}X_{Gal}
1216.6 345.0

Annotations:

^{1,3}X_{Man}Y Y^{1,3}X_{Man} ^{0,4}X_{Gal}Y Y^{0,4}X_{Gal}
1217.2 567.0
1217.6 144.0
1225.6 276.0

Annotations:

Z^{3,5}X_{GlcNAc} ^{3,5}X_{GlcNAc}Z
1233.4 219.0
1234.6 745.0
1256.5 1473.0
1257.5 1258.0

Annotations:

Y^{2,4}X_{GlcNAc} ^{2,4}X_{GlcNAc}Y
1258.5 300.0

Annotations:

YZ ZY YZ ZY
1259.5 906.0
1268.9 524.0

Annotations:

^{2,5}A_{Man}Z ^{2,5}A_{Man}Z
1275.3 1641.0
1275.7 906.0
1276.3 777.0

Annotations:

YY YY
1277.6 1002.0
1283.7 431.0
1299.5 1165.0

Annotations:

YZ ZY
1303.6 287.0
1345.7 307.0

Annotations:

Y^{1,5}X_{Gal} ^{1,5}X_{Gal}Y
1368.5 170.0
1377.7 457.0
1385.5 346.0
1387.5 459.0

Annotations:

Z Z
1388.5 1309.0
1389.5 983.0

Annotations:

^{0,3}X_{GlcNAc}Y Y^{0,3}X_{GlcNAc} ^{0,3}X_{Gal}Y Y^{0,3}X_{Gal}
1401.6 325.0

Annotations:

Z^{2,4}X_{GlcNAc} ^{0,4}X_{Gal}Z Z^{0,4}X_{Gal} ^{2,4}X_{GlcNAc}Z
1404.7 2399.0

Annotations:

^{2,4}A_{GlcNAc}Y ^{2,4}A_{GlcNAc}Y C^{0,2}X_{Gal} C^{0,2}X_{Gal}
1405.3 278.0

Annotations:

Y Y
1406.7 249.0
1407.8 202.0
1418.7 439.0

Annotations:

^{3,5}A_{GlcNAc}Y ^{3,5}A_{GlcNAc}Y
1419.5 177.0

Annotations:

Y^{2,4}X_{GlcNAc} ^{0,4}X_{Gal}Y Y^{0,4}X_{Gal} ^{2,4}X_{GlcNAc}Y
1420.7 506.0

Annotations:

C^{2,5}X_{Gal} C^{2,5}X_{Gal}
1421.5 260.0
1429.7 322.0

Annotations:

^{0,4}X_{NeuAc}Z Z^{0,4}X_{NeuAc}
1437.7 291.0
1438.6 753.0
1440.8 226.0
1453.5 735.0
1461.5 1807.0

Annotations:

YZ ZY YZ ZY
1462.7 456.0
1463.5 614.0
1479.6 874.0

Annotations:

YY YY
1480.7 2073.0
1481.5 566.0
1488.5 803.0

Annotations:

BZ BZ
1490.3 336.0
1506.5 1074.0

Annotations:

BY BY CZ CZ
1509.8 568.0
1523.6 914.0

Annotations:

^{1,3}X_{NeuAc}Y Y^{1,3}X_{NeuAc}
1529.9 260.0

Annotations:

BZ BZ
1532.4 417.0
1532.5 455.0
1540.7 128.0
1547.5 374.0

Annotations:

BY BY CZ CZ
1548.6 377.0

Annotations:

^{2,4}A_{GlcNAc}Z ^{2,4}A_{GlcNAc}Z
1549.7 427.0

Annotations:

Z Z
1550.5 145.0
1566.4 169.0

Annotations:

^{2,4}A_{GlcNAc}Y ^{2,4}A_{GlcNAc}Y
1567.6 5101.0

Annotations:

Y Y
1568.6 7977.0
1569.5 1893.0
1569.7 2534.0
1570.1 326.0
1570.6 1246.0
1571.6 512.0
1581.5 1209.0

Annotations:

Y^{0,4}X_{Gal} ^{0,4}X_{Gal}Y
1581.8 212.0

Annotations:

Y^{0,4}X_{Gal} ^{0,4}X_{Gal}Y
1582.7 567.0
1583.0 624.0
1599.5 647.0
1599.7 774.0
1611.6 642.0
1641.7 10399.0

Annotations:

YY
1642.7 3729.0
1643.8 2077.0
1644.6 1818.0
1645.6 340.0
1645.8 456.0
1650.7 211.0

Annotations:

^{0,2}X_{GlcNAc} ^{0,4}X_{NeuAc}Y Y^{0,4}X_{NeuAc} ^{0,2}X_{GlcNAc}
1652.0 557.0

Annotations:

^{2,4}X_{NeuAc}Z Z^{2,4}X_{NeuAc}
1668.9 253.0
1676.7 171.0
1695.8 627.0

Annotations:

C^{0,4}X_{NeuAc} C^{0,4}X_{NeuAc} ^{1,5}X_{NeuAc}Z Z^{1,5}X_{NeuAc}
1707.7 483.0
1709.7 3172.0

Annotations:

BY BY CZ CZ
1709.9 1823.0

Annotations:

BY BY CZ CZ
1710.5 2699.0

Annotations:

^{2,4}X_{GlcNAc} ^{2,4}X_{GlcNAc}
1711.6 2205.0

Annotations:

^{0,2}X_{NeuAc}Y Y^{0,2}X_{NeuAc}
1711.8 1848.0

Annotations:

^{0,2}X_{NeuAc}Y Y^{0,2}X_{NeuAc}
1712.8 1282.0
1713.7 1809.0

Annotations:

^{1,5}X_{NeuAc}Y Y^{1,5}X_{NeuAc}
1714.6 840.0

Annotations:

C^{2,4}X_{NeuAc} C^{2,4}X_{NeuAc}
1714.9 305.0

Annotations:

C^{2,4}X_{NeuAc} C^{2,4}X_{NeuAc}
1715.6 454.0
1719.8 513.0
1733.5 211.0
1734.7 879.0
1735.6 480.0
1735.8 1245.0
1737.5 252.0
1752.8 676.0

Annotations:

Z Z
1753.5 370.0

Annotations:

B^{1,3}X_{NeuAc} B^{1,3}X_{NeuAc}
1753.7 399.0

Annotations:

B^{1,3}X_{NeuAc} B^{1,3}X_{NeuAc}
1770.4 422.0

Annotations:

Y Y
1770.7 3055.0

Annotations:

Y Y
1771.7 2494.0

Annotations:

C^{1,3}X_{NeuAc} C^{1,3}X_{NeuAc}
1772.6 1556.0
1772.9 625.0
1774.8 862.0
1782.9 365.0
1783.8 848.0
1873.6 381.0
1874.7 250.0
1876.9 1233.0
1882.0 201.0
1891.6 289.0
1891.8 414.0
1911.0 1017.0
1914.7 1492.0

Annotations:

Z Z
1915.7 326.0
1916.1 1611.0
1916.7 2539.0
1917.5 417.0

Annotations:

C^{2,4}X_{NeuAc} C^{2,4}X_{NeuAc} ^{0,2}A_{GlcNAc}
1919.0 145.0
1931.5 454.0
1931.8 433.0
1932.8 122847.0

Annotations:

Y Y
1933.7 99131.0
1934.8 48901.0
1935.9 23075.0
1936.8 7987.0
1937.4 1507.0
1937.8 2144.0
1938.8 569.0
1939.0 388.0
1939.8 615.0

There are 11 similar spectra:

Id Structure Score

569

0.99

593

0.99

2386

0.97

2553

0.96

2387

0.87

2552

0.84

378

0.82

2390

0.77

616

0.73

3646

0.65

2392

0.59
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