In-depth N-glycome profiling of paired colorectal cancer and non-tumorigenic tissues reveals cancer-, stage- and EGFR-specific protein N-glycosylation.

PubMed Entry

GlyToucan Accession Number: G69996RR

Peak Intensity
290.1 1412.0

Annotations:

B
350.1 648.0

Annotations:

Z
368.2 244.0

Annotations:

Y
369.0 385.0

Annotations:

C^{2,4}X_{NeuAc}
382.1 322.0

Annotations:

C
383.1 134.0
383.8 106.0
406.2 352.0

Annotations:

B^{0,2}X_{Gal} B^{0,2}X_{Gal} ^{1,3}A_{Man}Z ^{0,4}A_{Man}Z ^{1,3}A_{Man}Z ^{2,4}A_{Man}Z
407.1 422.0

Annotations:

YZ ZY
424.0 241.0

Annotations:

^{1,5}A_{Gal} ^{1,3}A_{Man} ^{1,3}A_{Man}Y ^{0,4}A_{Man}Y ^{1,3}A_{Man}Y ^{2,4}A_{Man}Y C^{0,2}X_{Gal} C^{0,2}X_{Gal}
424.3 154.0

Annotations:

BY CZ
425.2 299.0

Annotations:

YY
428.1 120.0
452.0 264.0

Annotations:

B
466.2 246.0

Annotations:

B^{0,2}X_{GlcNAc} B^{1,3}X_{Gal} B^{2,4}X_{Gal} B^{0,4}X_{Gal} B^{1,3}X_{Gal} B^{2,4}X_{Gal}
470.3 275.0

Annotations:

C
476.2 180.0

Annotations:

^{2,5}A_{GlcNAc}Y
506.1 132.0
508.1 276.0

Annotations:

BZ
526.2 447.0

Annotations:

B
536.2 410.0
536.4 234.0
537.3 154.0
545.0 174.0
553.3 355.0

Annotations:

Z
554.3 141.0

Annotations:

B^{2,4}X_{NeuAc} ^{3,5}A_{GlcNAc}Z ^{1,4}A_{GlcNAc}Y
566.1 122.0
571.3 839.0

Annotations:

Y
572.4 144.0

Annotations:

^{0,2}A_{GlcNAc} C^{2,4}X_{NeuAc}
586.2 480.0

Annotations:

^{0,2}A_{Man}Y ^{0,4}A_{Man} ^{1,3}A_{Man}Y ^{2,4}A_{Man}Y ^{0,2}A_{GlcNAc}Y C^{1,3}X_{Gal} C^{2,4}X_{Gal} Y^{2,5}X_{Fuc}
587.3 275.0
597.4 108.0

Annotations:

B^{2,4}X_{GlcNAc}
615.7 176.0

Annotations:

^{0,3}A_{GlcNAc}Y C^{1,4}X_{GlcNAc} C^{1,5}X_{NeuAc}
637.3 112.0

Annotations:

YY
653.3 508.0
655.4 799.0

Annotations:

B
661.6 165.0
665.3 138.0

Annotations:

B^{3,5}X_{NeuAc} C^{2,5}X_{Gal} ^{1,5}X_{NeuAc}Y Y^{1,4}X_{Fuc} Y^{1,4}X_{Man} ^{1,4}X_{Gal}Y Y^{1,4}X_{GlcNAc} ^{1,4}X_{GlcNAc}Y Y^{0,3}X_{Gal} Y^{1,4}X_{Gal} ^{1,4}X_{Man}
670.2 396.0

Annotations:

BZ
673.4 299.0

Annotations:

C
688.3 154.0

Annotations:

BY CZ
697.2 173.0

Annotations:

ZZ
698.3 148.0
701.8 270.0

Annotations:

Z
702.7 282.0

Annotations:

YY
714.7 136.0

Annotations:

Z^{0,2}X_{Fuc} ^{2,5}A_{GlcNAc}Z
745.4 346.0

Annotations:

C^{3,5}X_{GlcNAc} ^{1,4}A_{Man} Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} Y^{1,5}X_{Gal} ^{1,5}X_{Gal}Y ^{0,2}X_{NeuAc}Y
750.2 304.0

Annotations:

^{1,5}A_{GlcNAc}Z
753.2 406.0

Annotations:

B
761.8 434.0

Annotations:

C
762.7 179.0

Annotations:

^{3,5}A_{GlcNAc}Y
763.4 181.0
773.8 286.0

Annotations:

YZ ZY
774.2 423.0

Annotations:

YZ ZY
774.7 154.0

Annotations:

YZ ZY
775.1 244.0

Annotations:

Y
782.7 1237.0

Annotations:

CY
783.3 1176.0

Annotations:

YY
783.8 995.0
784.3 378.0
785.3 236.0
786.0 301.0
793.3 684.0
797.2 115.0

Annotations:

B^{1,4}X_{NeuAc} ^{2,4}X_{NeuAc}Z ^{1,5}X_{GlcNAc}Y Y^{1,5}X_{Fuc}
800.8 124.0

Annotations:

^{1,4}A_{GlcNAc}Z
802.3 201.0

Annotations:

ZZ
804.3 183.0

Annotations:

^{1,5}A_{Man}Z Y^{0,2}X_{Fuc} ^{2,5}A_{GlcNAc}
812.3 387.0

Annotations:

Y
817.0 211.0

Annotations:

B
817.3 326.0

Annotations:

B
819.1 397.0

Annotations:

^{1,4}A_{GlcNAc}Y ^{1,4}X_{GlcNAc}Y Y^{0,3}X_{Fuc}
825.9 276.0

Annotations:

Y^{1,5}X_{Gal} ^{1,5}X_{Gal} ^{1,3}X_{Man} C^{3,5}X_{Gal} Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc}
830.5 347.0

Annotations:

^{0,3}X_{GlcNAc}Z
835.3 5524.0

Annotations:

C
835.8 226.0

Annotations:

^{1,3}X_{Man}Y Y^{1,3}X_{Man}
836.3 1144.0
836.8 309.0
837.3 697.0
838.3 623.0

Annotations:

^{0,2}X_{NeuAc}Z ^{3,5}X_{GlcNAc}Z
845.9 376.0

Annotations:

^{2,4}X_{GlcNAc}Z ^{0,2}X_{NeuAc}Z ^{2,5}X_{NeuAc}Z
846.8 181.0

Annotations:

^{1,5}X_{NeuAc}Z
854.9 527.0

Annotations:

^{2,4}X_{GlcNAc}Y ^{0,2}X_{NeuAc}Y ^{2,5}X_{NeuAc}Y Z^{3,5}X_{Fuc}
855.3 254.0

Annotations:

^{2,4}X_{GlcNAc}Y ^{0,2}X_{NeuAc}Y ^{2,5}X_{NeuAc}Y Z^{3,5}X_{Fuc}
855.7 130.0

Annotations:

^{0,2}X_{NeuAc}Y ^{2,5}X_{NeuAc}Y Z^{3,5}X_{Fuc}
856.1 449.0

Annotations:

Y
856.7 884.0

Annotations:

Y
857.3 131.0
866.8 152.0

Annotations:

ZZ
867.3 640.0

Annotations:

ZZ
875.7 289.0

Annotations:

YZ ZY
876.3 448.0

Annotations:

ZY YZ
876.5 283.0
876.9 688.0

Annotations:

YZ ZY YZ ZY
877.3 332.0

Annotations:

YZ ZY YZ ZY
877.8 133.0

Annotations:

YZ ZY YZ ZY
884.3 410.0

Annotations:

Z
884.7 299.0

Annotations:

Z
885.3 151.0

Annotations:

YY
886.3 139.0
887.2 130.0
891.4 120.0

Annotations:

BY CZ
892.4 112.0

Annotations:

^{2,4}A_{GlcNAc}Z ^{1,4}X_{GlcNAc}
893.5 288.0

Annotations:

Y
894.0 248.0
895.6 376.0

Annotations:

YY YY
897.9 319.0

Annotations:

^{0,2}X_{GlcNAc} ^{0,4}X_{NeuAc}Y ^{2,4}X_{NeuAc}Z
907.1 101.0

Annotations:

^{1,4}A_{Man} ^{2,4}X_{NeuAc}Y
907.4 204.0

Annotations:

^{1,4}A_{Man} ^{2,4}X_{NeuAc}Y
911.4 124.0

Annotations:

^{0,3}X_{Gal}Z ^{1,4}X_{Gal}Z Z^{0,3}X_{Fuc}
913.3 126.0

Annotations:

^{0,3}X_{GlcNAc} Y^{1,4}X_{Fuc}
914.9 473.0

Annotations:

^{2,4}X_{NeuAc}Y
918.9 404.0

Annotations:

Z^{1,3}X_{Fuc} Z^{2,4}X_{Fuc} B^{1,5}X_{Man}
919.3 470.0

Annotations:

Z^{1,3}X_{Fuc} Z^{2,4}X_{Fuc} B^{1,5}X_{Man}
920.4 171.0

Annotations:

^{0,3}X_{Gal}Y ^{1,4}X_{Gal}Y Y^{0,3}X_{Fuc} ^{3,5}X_{GlcNAc}
921.9 177.0

Annotations:

B^{1,4}X_{GlcNAc} ^{0,3}A_{GlcNAc}Z
926.5 316.0

Annotations:

^{0,4}X_{Gal}Z ^{1,3}X_{Gal}Z ^{2,4}X_{Gal}Z Z^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Z
926.9 397.0

Annotations:

^{0,4}X_{Gal}Z ^{1,3}X_{Gal}Z ^{2,4}X_{Gal}Z Z^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Z
927.4 477.0

Annotations:

Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} ^{2,4}X_{GlcNAc}
927.9 591.0

Annotations:

^{0,2}X_{NeuAc} Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} ^{2,4}X_{GlcNAc}
928.7 212.0

Annotations:

^{0,2}X_{NeuAc} ^{3,5}X_{Gal}Y Y^{3,5}X_{Fuc}
929.4 187.0

Annotations:

^{1,5}X_{NeuAc}
935.8 1367.0

Annotations:

^{0,4}X_{Gal}Y ^{1,3}X_{Gal}Y ^{2,4}X_{Gal}Y Y^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Y
936.4 313.0

Annotations:

^{2,5}A_{GlcNAc}Z ^{2,5}X_{NeuAc}
936.9 540.0

Annotations:

C^{1,5}X_{Man}
939.9 177.0

Annotations:

C^{1,4}X_{GlcNAc} ^{0,3}A_{GlcNAc}Y
944.1 323.0

Annotations:

^{1,3}X_{NeuAc}Y
948.6 482.0

Annotations:

Z
948.9 1124.0

Annotations:

Z
949.3 707.0

Annotations:

Z
949.9 506.0
956.9 6928.0

Annotations:

Z
957.4 4600.0

Annotations:

Y
957.9 4040.0

Annotations:

Y
958.4 2334.0
958.6 1392.0
958.8 730.0
959.4 931.0
960.9 256.0

Annotations:

BZ
961.3 135.0

Annotations:

BZ
965.9 317.0

Annotations:

Y
966.4 158.0
966.8 320.0
967.0 166.0

Annotations:

C^{2,5}X_{GlcNAc} ^{1,4}X_{GlcNAc}Y Y^{1,4}X_{Man} ^{1,4}X_{Man}Y Y^{1,4}X_{GlcNAc}
968.0 116.0
972.3 148.0

Annotations:

^{1,5}X_{Gal}
973.3 176.0
978.3 270.0

Annotations:

Y^{0,2}X_{GlcNAc} ^{0,2}X_{GlcNAc}Y
978.8 830.0

Annotations:

Y^{0,2}X_{GlcNAc} ^{0,2}X_{Gal} ^{0,4}X_{NeuAc} ^{0,2}X_{GlcNAc}Y
979.2 110.0

Annotations:

BY CZ
979.5 185.0

Annotations:

BY CZ
980.5 111.0
987.4 256.0
987.6 205.0
987.9 290.0

Annotations:

^{2,4}X_{NeuAc}
988.4 186.0

Annotations:

^{2,4}X_{NeuAc}
990.8 157.0

Annotations:

^{0,3}X_{GlcNAc}Z Z^{0,3}X_{GlcNAc}
995.5 103.0

Annotations:

^{2,5}A_{Man}Y
997.7 181.0

Annotations:

CY
1000.4 455.0
1002.9 159.0
1007.7 101.0

Annotations:

B^{1,5}X_{Man} ^{1,5}A_{Man}Z ^{1,5}A_{GlcNAc}Z
1008.9 3172.0

Annotations:

^{1,3}X_{Fuc} ^{2,4}X_{Fuc} ^{0,4}X_{Gal} ^{1,3}X_{Gal} ^{2,4}X_{Gal}
1009.4 2026.0

Annotations:

^{3,5}X_{Fuc}
1009.9 1002.0

Annotations:

^{3,5}X_{Fuc}
1010.4 444.0
1012.5 180.0
1017.9 1792.0
1018.4 2217.0
1018.9 699.0
1019.4 365.0
1019.5 348.0
1020.3 218.0

Annotations:

^{2,4}X_{GlcNAc}Z Z^{2,4}X_{GlcNAc}
1022.8 424.0
1023.3 244.0
1028.9 900.0
1029.3 186.0
1029.7 560.0
1029.9 1682.0
1030.3 782.0
1030.5 1278.0
1030.9 930.0
1055.1 101.0
1096.2 403.0

Annotations:

YZ ZY
1099.4 114.0

Annotations:

C^{1,5}X_{GlcNAc} C^{1,5}X_{Gal} ^{0,2}A_{GlcNAc}Y C^{1,3}X_{Man} ^{0,2}A_{Man}Y
1113.4 250.0

Annotations:

^{2,4}A_{GlcNAc}Y ^{1,5}A_{Man}Y C^{0,2}X_{Gal}
1115.3 345.0
1159.5 279.0

Annotations:

CY
1161.1 322.0
1201.1 109.0

Annotations:

^{2,4}A_{GlcNAc}Y
1201.3 185.0

Annotations:

^{2,4}A_{GlcNAc}Y
1216.5 308.0

Annotations:

^{1,3}X_{Man}Y Y^{0,4}X_{Fuc}
1218.4 422.0
1242.4 151.0

Annotations:

Z
1256.5 113.0

Annotations:

BY CZ
1258.5 190.0

Annotations:

YZ ZY
1260.5 116.0

Annotations:

Y
1261.6 512.0

Annotations:

^{0,2}A_{GlcNAc}Y
1262.7 372.0
1275.5 187.0

Annotations:

^{2,4}A_{GlcNAc}Y
1276.4 348.0

Annotations:

YY
1276.7 157.0

Annotations:

YY
1320.5 194.0
1326.5 156.0

Annotations:

BZ BZ
1341.5 138.0

Annotations:

^{0,2}X_{GlcNAc}Z Z^{2,5}X_{GlcNAc} ^{2,5}X_{GlcNAc}Z
1344.5 117.0

Annotations:

BY CZ BY CZ
1345.4 367.0
1362.4 807.0

Annotations:

CY CY
1369.4 150.0

Annotations:

ZZ
1386.4 368.0

Annotations:

ZZ
1386.6 174.0

Annotations:

ZZ
1387.5 131.0

Annotations:

YZ ZY
1401.5 334.0

Annotations:

^{2,4}X_{GlcNAc}Z
1402.7 216.0

Annotations:

B^{2,5}X_{Gal}
1406.5 118.0
1418.6 113.0

Annotations:

CZ BY
1419.5 158.0

Annotations:

^{2,4}X_{GlcNAc}Y
1420.6 277.0

Annotations:

C^{2,5}X_{Gal}
1421.4 122.0
1421.6 112.0
1422.2 443.0

Annotations:

Y
1422.4 169.0

Annotations:

Y
1422.7 110.0

Annotations:

Y
1423.6 166.0

Annotations:

C^{2,4}X_{NeuAc}
1424.8 126.0
1425.5 269.0
1426.7 196.0
1461.4 309.0

Annotations:

YZ ZY
1462.3 344.0

Annotations:

B^{1,3}X_{NeuAc}
1462.7 144.0

Annotations:

B^{1,3}X_{NeuAc}
1463.6 121.0

Annotations:

YY
1464.4 168.0

Annotations:

^{0,2}A_{Man} ^{0,2}A_{GlcNAc}Y C^{0,4}X_{Gal} C^{1,3}X_{Gal} C^{2,4}X_{Gal}
1464.5 201.0

Annotations:

^{0,2}A_{Man} ^{0,2}A_{GlcNAc}Y C^{0,4}X_{Gal} C^{1,3}X_{Gal} C^{2,4}X_{Gal}
1482.6 294.0
1491.6 114.0

Annotations:

C^{3,5}X_{GlcNAc} Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} Y^{1,5}X_{Gal} ^{1,5}X_{Gal}Y
1506.6 1980.0

Annotations:

B
1507.6 1127.0

Annotations:

^{1,5}X_{Gal}Y ^{1,3}X_{Man}Y Y^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Y Y^{1,5}X_{Fuc}
1507.8 297.0

Annotations:

^{1,3}X_{Man}Y ^{1,5}X_{Gal}Y Y^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Y Y^{1,5}X_{Fuc}
1508.6 567.0

Annotations:

C^{1,5}X_{NeuAc} ^{2,5}X_{NeuAc}Y
1509.8 138.0
1517.6 191.0

Annotations:

Z^{0,3}X_{GlcNAc} ^{1,4}X_{Gal}Z Z^{1,4}X_{Fuc} Z^{0,3}X_{Gal} Z^{1,4}X_{Gal}
1524.6 4715.0

Annotations:

C
1525.6 3415.0
1526.4 386.0
1526.6 982.0
1527.0 157.0
1527.4 207.0
1527.6 465.0
1528.7 168.0
1529.6 158.0

Annotations:

BZ
1547.6 128.0

Annotations:

BY CZ
1548.7 322.0
1549.4 102.0

Annotations:

YZ ZY
1550.6 254.0
1551.5 217.0

Annotations:

Y
1551.7 210.0

Annotations:

Y
1552.5 254.0

Annotations:

C^{3,5}X_{NeuAc}
1552.8 162.0

Annotations:

C^{3,5}X_{NeuAc}
1559.6 104.0
1565.7 224.0

Annotations:

CY
1566.6 249.0

Annotations:

^{2,4}A_{GlcNAc}
1566.8 296.0

Annotations:

^{2,4}A_{GlcNAc}
1567.6 430.0

Annotations:

YY
1581.7 240.0

Annotations:

^{1,3}X_{Gal}Y ^{2,4}X_{Gal}Y Y^{0,4}X_{Fuc}
1583.7 140.0
1584.8 320.0
1590.6 273.0
1607.7 758.0

Annotations:

Z
1608.5 393.0

Annotations:

B^{2,4}X_{NeuAc}
1608.8 112.0

Annotations:

B^{2,4}X_{NeuAc}
1609.5 296.0

Annotations:

Y^{0,2}X_{Fuc}
1610.5 222.0

Annotations:

^{2,5}A_{GlcNAc}
1623.4 438.0

Annotations:

YZ ZY
1624.5 201.0
1624.8 191.0
1625.7 626.0

Annotations:

Y
1626.7 1556.0

Annotations:

C^{2,4}X_{NeuAc} ^{0,2}A_{GlcNAc}
1627.4 279.0
1627.8 245.0
1628.8 256.0
1629.7 231.0
1651.4 257.0

Annotations:

Z^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Z Z^{1,5}X_{Fuc}
1651.8 126.0

Annotations:

Z^{0,4}X_{Fuc} ^{1,3}X_{NeuAc}Z Z^{1,5}X_{Fuc}
1668.6 114.0
1685.6 118.0
1686.8 169.0
1691.6 249.0
1695.6 220.0

Annotations:

Z
1709.6 785.0

Annotations:

B
1709.9 237.0

Annotations:

B
1710.5 1229.0

Annotations:

^{2,4}X_{GlcNAc}Y
1711.7 323.0

Annotations:

^{0,2}X_{NeuAc}Y ^{2,5}X_{NeuAc}Y Z^{3,5}X_{Fuc}
1712.6 553.0
1713.4 185.0

Annotations:

Y
1714.5 123.0
1725.5 168.0

Annotations:

^{0,3}X_{NeuAc}Y Z^{0,4}X_{Fuc}
1727.6 944.0

Annotations:

C
1728.7 681.0
1729.7 219.0

Annotations:

Y^{3,5}X_{Fuc}
1730.9 170.0
1731.8 253.0
1735.8 272.0
1745.6 226.0
1745.9 149.0
1748.9 383.0
1755.6 127.0
1770.9 131.0

Annotations:

YY
1786.8 288.0
1787.7 3056.0

Annotations:

Y
1788.7 2484.0
1788.8 2774.0
1789.7 990.0
1789.8 747.0
1790.7 619.0
1791.8 347.0
1827.8 125.0
1830.8 110.0
1949.8 120.0

There are 6 similar spectra:

Id Structure Score

2246

0.75

2539

0.75

2364

0.66

2367

0.65

2362

0.62

3643

0.55
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