Cystic fibrosis and bacterial colonization define the sputum N-glycosylation phenotype

PubMed Entry

GlyToucan Accession Number: G74784VI

Peak Intensity
290.1 203.0

Annotations:

B
294.1 283.0

Annotations:

^{1,4}X_{GlcNAc}
305.1 201.0

Annotations:

BZ BZ
305.2 200.0

Annotations:

BZ BZ
323.1 2389.0

Annotations:

BY CZ BY BY CZ CZ
347.1 122.0
365.1 265.0

Annotations:

YZ ZY
366.1 138.0

Annotations:

^{2,5}A_{GlcNAc}Z ^{2,5}A_{Man}Z
383.0 137.0

Annotations:

^{0,4}A_{Man}Y ^{0,2}A_{Man}Y ^{0,4}A_{Man}Y C^{0,2}X_{Man} C^{0,2}X_{Man} ^{0,2}A_{GlcNAc}Y C^{1,3}X_{Man}
383.3 116.0

Annotations:

^{0,4}A_{Man}Y C^{0,2}X_{Man} C^{0,2}X_{Man} C^{1,3}X_{Man} ^{0,4}A_{Man}Y ^{0,2}A_{GlcNAc}Y ^{0,2}A_{Man}Y
392.0 128.0

Annotations:

B^{1,5}X_{Gal}
434.1 140.0

Annotations:

CY
450.3 215.0

Annotations:

B^{2,5}X_{NeuAc}
452.2 261.0

Annotations:

B
467.1 143.0

Annotations:

YZ ZY
470.2 203.0

Annotations:

C
485.0 344.0

Annotations:

B
485.2 743.0

Annotations:

B
486.1 163.0
486.3 488.0
487.4 164.0

Annotations:

^{0,2}X_{Gal}Z Z^{0,2}X_{Man}
503.2 578.0

Annotations:

C
519.3 123.0

Annotations:

^{2,4}A_{GlcNAc}Y C^{0,2}X_{Man} B^{1,5}X_{GlcNAc} B^{1,5}X_{Gal} ^{3,5}X_{Gal}Y
545.1 362.0

Annotations:

^{0,4}A_{Man}
546.3 274.0
573.3 143.0
593.3 150.0

Annotations:

^{1,5}A_{GlcNAc}Y
599.3 269.0

Annotations:

CY
600.2 177.0

Annotations:

CY
600.6 287.0

Annotations:

^{3,5}X_{GlcNAc}Y ^{3,5}X_{GlcNAc}Y
600.9 116.0

Annotations:

^{3,5}X_{GlcNAc}Y ^{3,5}X_{GlcNAc}Y
623.2 293.0

Annotations:

^{0,3}A_{GlcNAc}Z
629.2 338.0

Annotations:

YZ YZ ZY ZY BZ
631.3 247.0

Annotations:

^{1,5}X_{GlcNAc} C^{1,5}X_{NeuAc} ^{0,3}A_{GlcNAc}Y
632.0 253.0

Annotations:

C^{1,5}X_{NeuAc} ^{0,3}A_{GlcNAc}Y
647.3 893.0

Annotations:

BY CZ
648.4 238.0
651.3 369.0

Annotations:

CZ CZ BY BY
651.9 358.0

Annotations:

Y^{1,5}X_{Man} ^{2,4}X_{NeuAc}Y ^{1,5}X_{Gal}Y ^{1,5}X_{Gal}Y Y^{1,5}X_{Man} ^{1,4}A_{GlcNAc}Y C^{0,3}X_{Gal}
655.3 2822.0

Annotations:

B
656.3 803.0
657.2 547.0
660.3 311.0

Annotations:

CY CY
673.3 489.0

Annotations:

C
674.4 255.0

Annotations:

C^{1,5}X_{Man} C^{1,5}X_{Man} ^{1,5}A_{GlcNAc}Y B^{1,4}X_{NeuAc}
681.3 3329.0

Annotations:

^{2,4}A_{GlcNAc}Y ^{2,4}A_{GlcNAc}Y C^{0,2}X_{Man} C^{0,2}X_{Man} C^{0,4}X_{NeuAc} B^{2,4}X_{NeuAc} ^{3,5}X_{Gal}Y ^{3,5}X_{Gal}Y Y^{3,5}X_{Man} Y^{3,5}X_{Man} ^{3,5}X_{GlcNAc}
681.8 1936.0

Annotations:

B^{2,4}X_{NeuAc} ^{3,5}X_{Gal}Y ^{3,5}X_{Gal}Y Y^{3,5}X_{Man} Y^{3,5}X_{Man} ^{3,5}X_{GlcNAc}
682.2 846.0

Annotations:

^{3,5}X_{Gal}Y ^{3,5}X_{Gal}Y Y^{3,5}X_{Man} Y^{3,5}X_{Man} ^{3,5}X_{GlcNAc} B^{2,4}X_{NeuAc}
682.5 352.0
682.7 440.0
695.3 238.0

Annotations:

B^{3,5}X_{Man} B^{3,5}X_{Man}
697.2 180.0

Annotations:

CY
702.8 106.0

Annotations:

^{3,5}A_{GlcNAc}Z ^{2,5}A_{GlcNAc}Y ^{2,5}A_{GlcNAc}Y ^{2,5}A_{Man}
705.0 126.0
707.4 143.0

Annotations:

^{2,4}A_{GlcNAc}Y ^{1,4}A_{GlcNAc}Z ^{1,4}A_{GlcNAc}Z
708.2 106.0

Annotations:

^{1,4}A_{GlcNAc}Z ^{1,4}A_{GlcNAc}Z
715.3 160.0

Annotations:

^{1,3}A_{Man} C^{0,4}X_{NeuAc}
716.5 119.0

Annotations:

B^{2,4}X_{NeuAc} ^{1,5}X_{Man} ^{1,4}A_{GlcNAc}Y ^{1,4}A_{GlcNAc}Y
717.1 167.0

Annotations:

^{1,4}A_{GlcNAc}Y ^{1,4}A_{GlcNAc}Y
725.8 192.0
731.9 136.0

Annotations:

B
732.4 204.0

Annotations:

B
732.7 205.0

Annotations:

B
733.3 102.0

Annotations:

C^{1,5}X_{NeuAc} ^{2,5}A_{GlcNAc}Z ^{2,5}A_{Man}Z
741.2 205.0

Annotations:

C
742.3 530.0
752.8 127.0

Annotations:

BY BY CZ CZ
753.3 1092.0

Annotations:

^{0,2}X_{NeuAc}Y ^{0,2}X_{NeuAc}Y Z^{3,5}X_{Man} Z^{3,5}X_{Man}
753.7 803.0

Annotations:

^{0,2}X_{NeuAc}Y ^{0,2}X_{NeuAc}Y Z^{3,5}X_{Man} Z^{3,5}X_{Man}
754.1 139.0

Annotations:

^{0,2}X_{NeuAc}Y ^{0,2}X_{NeuAc}Y Z^{3,5}X_{Man} Z^{3,5}X_{Man}
757.1 268.0
762.3 8454.0

Annotations:

^{2,4}A_{GlcNAc} Y^{3,5}X_{Man} Y^{3,5}X_{Man} ^{3,5}X_{Gal}
762.8 6454.0

Annotations:

Y^{3,5}X_{Man} Y^{3,5}X_{Man} ^{3,5}X_{Gal} ^{1,5}A_{Man}Z
763.3 2525.0

Annotations:

^{1,5}A_{Man}Z
763.8 1389.0
764.3 124.0
769.7 142.0

Annotations:

^{3,5}A_{GlcNAc} Y^{0,4}X_{Man} Y^{1,3}X_{Man} Y^{2,4}X_{Man} Y^{0,4}X_{Man} Y^{1,3}X_{Man} Y^{2,4}X_{Man} ^{0,4}X_{Gal}
773.1 249.0

Annotations:

B^{1,3}X_{NeuAc} Z^{0,2}X_{Man}
775.4 329.0

Annotations:

C^{1,5}X_{Man} C^{1,5}X_{Man}
783.3 116.0

Annotations:

YY
783.7 156.0

Annotations:

YY
783.9 169.0

Annotations:

^{2,5}A_{GlcNAc}
792.3 257.0

Annotations:

C^{2,4}X_{NeuAc} ^{0,2}A_{GlcNAc}
793.3 259.0
794.1 112.0
794.4 182.0
795.3 173.0

Annotations:

^{0,2}X_{Man}Z Z^{0,2}X_{Man} ^{0,4}X_{NeuAc}Z ^{0,4}X_{NeuAc}Z
799.3 119.0

Annotations:

Y
801.0 158.0
804.3 151.0

Annotations:

^{1,5}A_{GlcNAc}Z ^{0,2}X_{Man}Y Y^{0,2}X_{Man} ^{0,4}X_{NeuAc}Y ^{0,4}X_{NeuAc}Y ^{2,4}X_{NeuAc}Z ^{2,4}X_{NeuAc}Z
804.8 289.0

Annotations:

^{2,4}X_{NeuAc}Z ^{2,4}X_{NeuAc}Z
808.8 124.0

Annotations:

BY CZ
813.3 2161.0

Annotations:

^{2,4}X_{NeuAc}Y ^{2,4}X_{NeuAc}Y
813.8 720.0

Annotations:

^{2,4}X_{NeuAc}Y ^{2,4}X_{NeuAc}Y
814.3 584.0

Annotations:

^{0,2}X_{GlcNAc}Z
817.3 5078.0

Annotations:

B
818.4 976.0

Annotations:

^{3,5}X_{Man}Z Z^{3,5}X_{Man}
819.3 1763.0

Annotations:

Y^{1,4}X_{Man} ^{1,5}A_{GlcNAc} ^{0,3}X_{Man}Y ^{1,4}X_{Man}Y Y^{0,3}X_{Man}
820.3 140.0

Annotations:

C^{1,3}X_{NeuAc}
820.5 229.0

Annotations:

C^{1,3}X_{NeuAc}
825.3 582.0

Annotations:

^{0,4}X_{Man}Z ^{1,3}X_{Man}Z ^{2,4}X_{Man}Z Z^{0,4}X_{Man} Z^{1,3}X_{Man} Z^{2,4}X_{Man}
833.8 238.0

Annotations:

B
834.4 1256.0

Annotations:

^{0,4}X_{Man}Y ^{1,3}X_{Man}Y ^{2,4}X_{Man}Y Y^{0,4}X_{Man} Y^{1,3}X_{Man} Y^{2,4}X_{Man} ^{0,2}X_{NeuAc}
835.3 11677.0

Annotations:

C
835.8 400.0

Annotations:

^{1,5}X_{NeuAc}
836.3 4571.0
837.3 1124.0

Annotations:

B^{1,5}X_{GlcNAc}
838.3 555.0
839.3 101.0
839.9 290.0
841.2 178.0
843.4 218.0
843.8 325.0
854.8 246.0

Annotations:

Z Z
855.4 328.0

Annotations:

Z Z
855.8 350.0
856.0 263.0
856.2 138.0
856.4 115.0
859.5 129.0
864.3 753.0

Annotations:

Y Y
864.7 791.0

Annotations:

Y Y
865.4 733.0

Annotations:

^{3,5}A_{GlcNAc}Z
865.7 271.0

Annotations:

^{3,5}A_{GlcNAc}Z
866.2 547.0
868.1 112.0

Annotations:

CY
870.3 129.0
871.9 119.0
876.4 215.0
876.8 165.0

Annotations:

^{2,4}A_{Man} ^{1,3}A_{Man}
877.2 234.0

Annotations:

^{2,4}A_{Man} ^{1,3}A_{Man}
877.4 229.0

Annotations:

^{1,3}A_{Man} ^{2,4}A_{Man}
881.8 178.0
883.4 103.0

Annotations:

^{3,5}A_{GlcNAc}Y
885.4 774.0

Annotations:

^{0,2}X_{Man} ^{0,4}X_{NeuAc} ^{0,2}X_{Man}
885.9 422.0
886.1 341.0
886.4 209.0
886.7 174.0
887.8 162.0

Annotations:

^{1,4}X_{NeuAc}
893.1 135.0

Annotations:

YZ YZ ZY ZY
894.3 1412.0
894.8 688.0

Annotations:

^{2,4}X_{NeuAc} ^{2,5}A_{GlcNAc}Z
895.5 188.0

Annotations:

^{2,5}A_{GlcNAc}Z
895.8 597.0

Annotations:

C^{1,5}X_{Man}
896.6 128.0

Annotations:

C^{1,5}X_{Man}
897.3 132.0
903.5 249.0
907.2 306.0

Annotations:

^{1,4}A_{Man}
907.8 147.0

Annotations:

^{1,4}A_{Man} B^{2,5}X_{GlcNAc}
908.3 189.0

Annotations:

B^{2,5}X_{GlcNAc} ^{3,5}X_{Man} ^{3,5}X_{Man}
908.6 139.0

Annotations:

B^{2,5}X_{GlcNAc} ^{3,5}X_{Man} ^{3,5}X_{Man}
909.4 148.0
910.3 257.0

Annotations:

C^{0,2}X_{GlcNAc}
913.9 138.0
915.4 4727.0

Annotations:

^{0,4}X_{Man} ^{1,3}X_{Man} ^{2,4}X_{Man} ^{0,4}X_{Man} ^{1,3}X_{Man} ^{2,4}X_{Man}
915.9 3177.0

Annotations:

ZZ
916.4 1434.0

Annotations:

ZZ
916.8 971.0

Annotations:

ZZ
917.4 202.0
918.0 255.0
920.5 116.0
923.9 259.0
924.3 1104.0
925.0 543.0
925.4 316.0
925.8 128.0

Annotations:

C^{2,5}X_{GlcNAc}
927.1 398.0
929.4 125.0

Annotations:

^{0,2}A_{GlcNAc}Y
934.9 184.0

Annotations:

Z^{0,2}X_{Man} Z^{0,2}X_{Man}
935.8 231.0

Annotations:

Z^{0,2}X_{Man} Z^{0,2}X_{Man}
936.0 169.0

Annotations:

^{2,5}A_{Man}Z
936.3 131.0

Annotations:

^{2,5}A_{Man}Z
937.5 232.0
937.7 115.0
938.0 176.0

Annotations:

B^{3,5}X_{GlcNAc}
971.4 171.0
974.5 226.0
996.7 109.0
1003.3 374.0
1006.3 135.0

Annotations:

^{0,3}X_{Gal}Z
1014.4 301.0
1039.4 341.0

Annotations:

^{2,4}A_{GlcNAc}Y C^{0,2}X_{Man}
1041.6 155.0
1042.3 186.0
1054.3 187.0

Annotations:

^{2,4}A_{GlcNAc}Z B^{0,2}X_{Gal} ^{0,4}X_{Gal}Y
1072.4 177.0

Annotations:

^{2,4}A_{GlcNAc}Y C^{0,2}X_{Gal}
1073.4 150.0

Annotations:

Y
1074.2 250.0
1075.2 226.0
1079.5 105.0
1157.6 116.0

Annotations:

Z^{0,4}X_{Man} Z^{1,3}X_{Man} Z^{2,4}X_{Man} Z^{0,4}X_{Man} Z^{1,3}X_{Man} Z^{2,4}X_{Man}
1159.6 137.0

Annotations:

C^{3,5}X_{GlcNAc}
1195.3 188.0
1203.3 130.0
1234.5 110.0

Annotations:

^{2,4}A_{GlcNAc}Y
1235.4 200.0

Annotations:

Y
1248.4 125.0

Annotations:

^{3,5}A_{GlcNAc}Y
1286.3 108.0

Annotations:

Z^{1,5}X_{Man} ^{2,4}X_{NeuAc}Z ^{1,5}X_{Gal}Z ^{1,5}X_{Gal}Z Z^{1,5}X_{Man}
1303.4 279.0

Annotations:

BY BY CZ CZ
1304.7 216.0

Annotations:

Y^{1,5}X_{Man} Y^{1,5}X_{Man} ^{2,4}X_{NeuAc}Y ^{1,5}X_{Gal}Y ^{1,5}X_{Gal}Y
1321.6 313.0

Annotations:

CY CY
1323.8 191.0
1324.3 105.0
1345.4 139.0

Annotations:

^{2,4}A_{GlcNAc}Z ^{2,4}A_{GlcNAc}Z B^{0,2}X_{Man} B^{0,2}X_{Man} B^{0,4}X_{NeuAc}
1346.4 275.0

Annotations:

^{3,5}X_{Gal}Z ^{3,5}X_{Gal}Z Z^{3,5}X_{Man} Z^{3,5}X_{Man}
1348.3 189.0

Annotations:

^{0,3}X_{Gal}Y ^{0,3}X_{Gal}Y Y^{0,3}X_{Man} Y^{1,4}X_{Man} Y^{0,3}X_{Man} Y^{1,4}X_{Man} ^{0,3}X_{GlcNAc}
1360.5 184.0

Annotations:

^{0,4}X_{Gal}Z ^{0,4}X_{Gal}Z Z^{0,4}X_{Man} Z^{1,3}X_{Man} Z^{2,4}X_{Man} Z^{0,4}X_{Man} Z^{1,3}X_{Man} Z^{2,4}X_{Man}
1367.5 109.0
1377.4 174.0

Annotations:

BY CZ
1379.4 142.0

Annotations:

C^{2,5}X_{Man} C^{2,5}X_{Man}
1388.3 141.0
1406.4 114.0
1420.5 166.0

Annotations:

Z
1422.6 117.0
1423.4 162.0

Annotations:

C^{0,4}X_{Man} ^{0,2}A_{GlcNAc}Y ^{0,2}A_{GlcNAc}Y C^{1,3}X_{Man} C^{2,4}X_{Man} C^{0,4}X_{Man} C^{1,3}X_{Man} C^{2,4}X_{Man} ^{0,2}A_{Man}
1423.6 163.0

Annotations:

^{0,2}A_{GlcNAc}Y ^{0,2}A_{GlcNAc}Y C^{0,4}X_{Man} C^{1,3}X_{Man} C^{2,4}X_{Man} C^{0,4}X_{Man} C^{1,3}X_{Man} C^{2,4}X_{Man} ^{0,2}A_{Man}
1438.5 201.0

Annotations:

Y
1440.6 255.0
1464.0 112.0

Annotations:

^{2,5}X_{Man}
1465.4 194.0

Annotations:

B
1465.7 380.0

Annotations:

B
1466.5 223.0

Annotations:

Y^{1,5}X_{Man} Y^{1,5}X_{Man} ^{1,5}X_{Gal}
1468.3 287.0
1483.5 2903.0

Annotations:

C
1484.3 286.0
1484.6 1285.0
1485.5 295.0
1485.8 216.0
1488.5 186.0

Annotations:

BZ BZ
1489.7 151.0
1497.5 130.0
1506.6 177.0

Annotations:

BY BY CZ CZ
1507.5 164.0
1521.6 101.0
1526.8 274.0

Annotations:

Y^{3,5}X_{Man} Y^{3,5}X_{Man} ^{3,5}X_{Gal}
1527.7 193.0
1540.8 198.0

Annotations:

Y^{0,4}X_{Man} Y^{1,3}X_{Man} Y^{2,4}X_{Man} Y^{0,4}X_{Man} Y^{1,3}X_{Man} Y^{2,4}X_{Man} ^{0,4}X_{Gal}
1541.5 246.0
1542.5 141.0
1547.3 128.0
1585.6 248.0

Annotations:

C^{2,4}X_{NeuAc} ^{0,2}A_{GlcNAc}
1585.8 490.0

Annotations:

C^{2,4}X_{NeuAc} ^{0,2}A_{GlcNAc}
1586.3 137.0
1587.3 137.0
1600.6 341.0

Annotations:

Y
1600.8 205.0

Annotations:

Y
1601.5 214.0
1602.5 160.0
1612.6 213.0

Annotations:

C^{3,5}X_{Man} C^{3,5}X_{Man}
1628.8 284.0

Annotations:

^{2,4}X_{NeuAc}Y ^{2,4}X_{NeuAc}Y
1629.4 117.0
1651.5 111.0

Annotations:

^{0,4}X_{Man}Z ^{1,3}X_{Man}Z ^{2,4}X_{Man}Z Z^{0,4}X_{Man} Z^{1,3}X_{Man} Z^{2,4}X_{Man}
1668.7 1647.0

Annotations:

B
1669.5 773.0

Annotations:

^{0,4}X_{Man}Y ^{1,3}X_{Man}Y ^{2,4}X_{Man}Y Y^{0,4}X_{Man} Y^{1,3}X_{Man} Y^{2,4}X_{Man}
1670.4 784.0

Annotations:

^{0,2}X_{NeuAc}
1671.5 125.0
1672.6 315.0

Annotations:

^{1,5}X_{NeuAc}
1686.5 118.0

Annotations:

C
1686.8 192.0

Annotations:

C
1687.7 308.0
1688.6 141.0
1688.8 141.0
1730.4 125.0
1773.6 129.0
1795.8 229.0
1832.4 149.0

There are 4 similar spectra:

Id Structure Score

2331

0.84

2332

0.78

2522

0.77

430

0.66
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