Cystic fibrosis and bacterial colonization define the sputum N-glycosylation phenotype

PubMed Entry

GlyToucan Accession Number: G37061YM

Peak Intensity
276.4 100.0

Annotations:

Z
281.1 137.0
290.1 663.0

Annotations:

B
304.1 141.0

Annotations:

B^{0,3}X_{NeuAc}
308.0 190.0

Annotations:

C
309.1 122.0
310.1 111.0

Annotations:

Y^{3,5}X_{Fuc}
323.1 105.0

Annotations:

BY CZ
326.4 195.0

Annotations:

BZ
350.2 416.0

Annotations:

Z
368.3 564.0

Annotations:

Y
372.2 103.0

Annotations:

C^{0,3}X_{Fuc} ^{1,4}A_{Man}Y ^{3,5}A_{Man}Y
388.8 284.0

Annotations:

ZZ
389.0 217.0

Annotations:

ZZ
407.2 249.0

Annotations:

YZ ZY BZ
408.1 185.0

Annotations:

BZ BY CZ
414.1 119.0
430.0 145.0

Annotations:

^{1,3}A_{Man} C^{0,4}X_{NeuAc}
451.3 188.0

Annotations:

B^{1,3}X_{Fuc} B^{2,4}X_{Fuc} ^{0,2}X_{GlcNAc}
452.2 159.0

Annotations:

B
467.2 146.0

Annotations:

BZ
470.2 2626.0

Annotations:

C
471.1 484.0
472.2 211.0
473.1 126.0

Annotations:

^{1,4}A_{GlcNAc}Z
503.3 169.0

Annotations:

CY
544.2 123.0

Annotations:

CY
545.2 581.0

Annotations:

^{2,4}A_{GlcNAc}Y
546.2 225.0
553.2 441.0

Annotations:

Z
570.2 131.0

Annotations:

BY CZ
571.1 179.0

Annotations:

Y
571.3 148.0

Annotations:

Y
572.3 141.0

Annotations:

C^{1,5}X_{Man}
573.4 184.0
587.4 209.0

Annotations:

^{0,2}A_{GlcNAc}Z
592.2 173.0

Annotations:

^{2,4}A_{GlcNAc}Y C^{0,4}X_{NeuAc} C^{0,2}X_{Man} B^{2,4}X_{NeuAc}
592.3 163.0

Annotations:

^{2,4}A_{GlcNAc}Y C^{0,4}X_{NeuAc} C^{0,2}X_{Man} B^{2,4}X_{NeuAc}
592.6 126.0

Annotations:

^{2,4}A_{GlcNAc}Y C^{0,4}X_{NeuAc} C^{0,2}X_{Man} B^{2,4}X_{NeuAc}
619.2 174.0

Annotations:

^{1,4}A_{GlcNAc}Z
637.2 313.0

Annotations:

BZ
655.2 702.0

Annotations:

BZ BY CZ
656.1 227.0
656.3 144.0

Annotations:

^{1,4}X_{Gal}Z Z^{1,4}X_{Gal} Z^{0,3}X_{Fuc} ^{0,3}X_{Fuc}Z ^{3,5}X_{Man}Z
664.9 293.0

Annotations:

Z^{3,5}X_{Fuc} ^{3,5}X_{Fuc}Z
666.0 126.0

Annotations:

^{1,4}X_{Gal}Y Y^{1,4}X_{Gal} Y^{0,3}X_{Fuc} ^{0,3}X_{Fuc}Y ^{3,5}X_{Man}Y C^{3,5}X_{NeuAc}
670.4 213.0

Annotations:

BZ
671.1 228.0
672.0 115.0

Annotations:

BY CZ CZ BY
672.3 142.0

Annotations:

BY CZ CY
673.3 711.0

Annotations:

CY
673.7 590.0

Annotations:

CY
674.1 268.0

Annotations:

Y^{3,5}X_{Fuc} ^{3,5}X_{Fuc}Y
688.3 172.0

Annotations:

BY CZ
688.5 280.0

Annotations:

CZ BY
689.2 267.0
691.2 124.0
697.5 130.0

Annotations:

ZZ
700.8 114.0

Annotations:

B^{2,5}X_{Fuc} C^{1,5}X_{Fuc}
701.2 123.0

Annotations:

B^{2,5}X_{Fuc} C^{1,5}X_{Fuc}
723.0 174.0

Annotations:

B^{0,4}X_{Fuc} B^{1,3}X_{NeuAc} Z^{0,2}X_{Fuc} ^{0,2}X_{Fuc}Z ^{2,5}X_{Man}Z
724.3 110.0

Annotations:

C^{3,5}X_{Fuc} ^{1,5}X_{Fuc}Y Y^{1,5}X_{Fuc}
725.2 137.0

Annotations:

C^{3,5}X_{Fuc} ^{1,5}X_{Fuc}Y Y^{1,5}X_{Fuc}
731.4 304.0

Annotations:

YZ ZY
732.1 183.0

Annotations:

C^{0,4}X_{Fuc} C^{1,3}X_{NeuAc} Y^{0,2}X_{Fuc} ^{0,2}X_{Fuc}Y ^{2,5}X_{Gal} ^{2,5}X_{Man}Y ^{0,4}A_{Man}Y
732.5 170.0

Annotations:

^{0,4}A_{Man}Y
737.0 200.0

Annotations:

^{0,2}X_{NeuAc}Z Z^{0,2}X_{NeuAc} Z^{2,5}X_{NeuAc}
745.3 819.0

Annotations:

^{3,5}X_{Fuc}Z Y^{2,5}X_{NeuAc} C^{0,3}X_{Fuc} ^{1,4}A_{Man}Y ^{0,2}X_{NeuAc}Y Z^{3,5}X_{Fuc} Y^{0,2}X_{NeuAc}
745.8 444.0

Annotations:

^{0,2}X_{NeuAc}Y Z^{3,5}X_{Fuc} Y^{0,2}X_{NeuAc} ^{3,5}X_{Fuc}Z Y^{2,5}X_{NeuAc} ^{3,5}A_{Man}Y
746.3 246.0

Annotations:

^{3,5}A_{Man}Y ^{1,5}X_{NeuAc}Y Y^{1,5}X_{NeuAc} Y^{0,3}X_{Fuc} ^{0,3}X_{Fuc}Y ^{3,5}X_{Man}Y
747.4 185.0
762.3 111.0

Annotations:

C^{1,5}X_{NeuAc} ^{0,3}A_{Man}Y
766.3 1218.0

Annotations:

ZY YZ YZ ZY
766.8 671.0
767.3 141.0
769.3 142.0
773.2 105.0

Annotations:

Z^{0,2}X_{Fuc} ^{2,5}X_{Man}Z
774.7 125.0

Annotations:

Z
781.8 203.0

Annotations:

Z^{1,4}X_{NeuAc}
791.1 185.0

Annotations:

Y^{1,4}X_{NeuAc} Y^{0,2}X_{Fuc} ^{2,5}X_{Man}Y
800.9 341.0

Annotations:

B
801.3 1387.0

Annotations:

B
802.2 1218.0

Annotations:

^{1,4}X_{Man}Z Z^{0,3}X_{Fuc} Z^{0,3}X_{Fuc} ^{1,4}X_{Fuc}Z Z^{1,4}X_{Fuc} ^{0,3}X_{Man}Z ^{0,3}X_{Man}Z ^{1,4}X_{Man}Z
803.3 317.0

Annotations:

^{2,5}X_{Fuc}Z Z^{2,5}X_{Fuc} ^{1,4}X_{Man}Z Z^{0,3}X_{Fuc} Y^{1,4}X_{Fuc} Y^{1,4}X_{Fuc} ^{3,5}X_{Man}Z
804.4 107.0

Annotations:

^{0,2}X_{Fuc}Y Y^{0,2}X_{Fuc} ^{2,5}X_{Man}Y ^{2,5}X_{Man}Y Y^{2,5}X_{Fuc} Y^{2,5}X_{Fuc}
805.4 166.0

Annotations:

Y^{1,4}X_{Fuc} ^{0,3}X_{Man}Y ^{1,4}X_{Man}Y Y^{1,4}X_{Man} ^{2,4}X_{NeuAc}Y Y^{2,4}X_{NeuAc}
808.3 178.0
813.3 232.0
816.4 181.0

Annotations:

BZ
817.3 659.0

Annotations:

BY CZ
817.8 196.0

Annotations:

Z^{1,3}X_{Fuc} Z^{2,4}X_{Fuc} ^{0,4}X_{Man}Z ^{1,3}X_{Man}Z ^{2,4}X_{Man}Z Z^{1,3}X_{Man} ^{3,5}X_{Fuc}Z Z^{3,5}X_{Fuc} Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc}
818.3 259.0

Annotations:

^{3,5}X_{Fuc}Z Z^{3,5}X_{Fuc} Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} ^{0,2}X_{NeuAc}
819.3 106.0

Annotations:

C
822.1 108.0
826.3 289.0

Annotations:

^{1,3}X_{Fuc}Y ^{2,4}X_{Fuc}Y Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} ^{0,4}X_{Man}Y ^{0,4}X_{Man}Y ^{1,3}X_{Man}Y ^{1,3}X_{Man}Y ^{2,4}X_{Man}Y ^{2,4}X_{Man}Y Y^{0,4}X_{Fuc} Y^{1,3}X_{NeuAc} Y^{0,4}X_{Fuc} ^{2,5}X_{NeuAc}
826.9 193.0

Annotations:

^{2,5}X_{NeuAc} ^{3,5}X_{Fuc}Y Y^{3,5}X_{Fuc}
827.4 483.0

Annotations:

^{3,5}X_{Fuc}Y Y^{3,5}X_{Fuc}
827.9 289.0
831.1 121.0
833.1 190.0

Annotations:

^{1,3}X_{Man}Z Z^{0,4}X_{Fuc}
833.4 188.0

Annotations:

^{1,3}X_{Man}Z Z^{0,4}X_{Fuc} ^{0,3}X_{NeuAc}
834.2 261.0

Annotations:

CZ BY
834.6 162.0

Annotations:

CZ BY
838.3 422.0
839.3 112.0

Annotations:

Z
840.3 171.0
843.3 136.0

Annotations:

B^{0,4}X_{NeuAc}
847.4 1696.0

Annotations:

Z Z
847.9 1818.0

Annotations:

Y
848.3 2424.0

Annotations:

Y
848.9 667.0
849.4 591.0
851.4 225.0

Annotations:

^{1,3}X_{Man}Y Y^{0,4}X_{Fuc}
852.4 309.0

Annotations:

CY
853.4 109.0
856.1 101.0

Annotations:

Y Y
860.3 116.0
861.4 518.0

Annotations:

^{1,3}A_{Man} C^{0,4}X_{NeuAc}
862.2 122.0

Annotations:

B^{1,5}X_{Gal} B^{2,4}X_{NeuAc} ^{1,5}X_{Man}
871.2 162.0
875.4 129.0

Annotations:

ZZ
885.0 204.0

Annotations:

^{2,5}X_{Fuc} ^{2,5}X_{Fuc}
885.6 172.0

Annotations:

^{2,5}X_{Fuc} ^{2,5}X_{Fuc}
888.4 186.0
889.9 108.0

Annotations:

^{3,5}A_{GlcNAc}Z
890.2 192.0

Annotations:

^{3,5}A_{GlcNAc}Z
893.4 917.0

Annotations:

YZ ZY
894.2 407.0

Annotations:

^{2,4}A_{GlcNAc}Y C^{0,2}X_{Gal}
894.5 395.0

Annotations:

^{2,4}A_{GlcNAc}Y C^{0,2}X_{Gal}
895.4 378.0

Annotations:

Y
896.4 332.0
896.6 126.0
898.1 203.0
899.5 406.0

Annotations:

^{1,3}X_{Fuc} ^{2,4}X_{Fuc} ^{1,3}X_{Fuc} ^{2,4}X_{Fuc} ^{0,4}X_{Man} ^{1,3}X_{Man} ^{2,4}X_{Man}
899.9 682.0

Annotations:

^{3,5}X_{Fuc} ^{3,5}X_{Fuc}
900.3 294.0

Annotations:

^{3,5}X_{Fuc} ^{3,5}X_{Fuc}
901.1 216.0
902.4 233.0
908.4 941.0

Annotations:

^{3,5}A_{GlcNAc}Y
908.9 153.0
909.3 102.0
909.5 129.0
913.5 132.0
918.3 130.0
919.1 192.0

Annotations:

B^{0,4}X_{Fuc} B^{1,3}X_{NeuAc} ^{0,2}X_{Man}Z
920.2 129.0

Annotations:

^{2,5}A_{GlcNAc}Z ^{2,5}A_{Man}Z
921.1 498.0

Annotations:

C^{1,3}X_{Fuc} C^{2,4}X_{Fuc} Z^{1,5}X_{Fuc}
922.0 149.0
938.4 102.0

Annotations:

^{2,5}A_{GlcNAc}Y ^{2,5}A_{Man}Y
945.7 108.0
963.5 515.0

Annotations:

B
981.2 136.0

Annotations:

C
981.5 342.0

Annotations:

C
982.3 154.0
984.4 118.0
987.3 142.0
988.4 147.0
989.3 398.0
989.6 272.0
997.4 173.0

Annotations:

Y^{1,3}X_{Fuc} Y^{2,4}X_{Fuc} ^{1,3}X_{Man} ^{0,4}X_{Man}Y ^{1,3}X_{Man}Y ^{2,4}X_{Man}Y
1001.3 222.0
1004.3 140.0
1005.3 201.0
1015.4 442.0
1018.4 403.0
1019.3 192.0

Annotations:

BZ
1020.6 103.0
1023.3 174.0

Annotations:

^{0,4}A_{Man}
1024.5 232.0
1026.4 122.0
1030.2 120.0
1031.3 165.0
1039.3 330.0

Annotations:

Z
1040.5 331.0
1042.2 126.0
1044.6 105.0
1046.3 110.0
1053.3 152.0

Annotations:

^{0,3}A_{Man}
1053.5 141.0

Annotations:

^{0,3}A_{Man}
1056.5 402.0

Annotations:

^{2,4}A_{GlcNAc}Y
1057.4 3519.0

Annotations:

Y
1058.4 2340.0
1059.5 332.0
1060.3 328.0
1060.5 574.0
1061.5 109.0
1064.4 102.0
1071.3 173.0
1080.3 183.0
1081.6 103.0

Annotations:

^{0,2}A_{Man}Z
1083.4 195.0

Annotations:

^{2,5}A_{Man}Y C^{1,5}X_{Gal}
1089.4 267.0
1107.4 964.0

Annotations:

BZ
1108.4 514.0
1108.6 182.0
1109.4 215.0

Annotations:

B^{1,4}X_{Gal} ^{1,4}A_{GlcNAc}Z
1125.4 1081.0

Annotations:

CZ BY
1126.5 342.0
1135.4 349.0
1141.5 118.0

Annotations:

BY CZ
1143.5 617.0

Annotations:

CY
1144.5 140.0
1149.3 200.0
1154.6 102.0
1164.4 233.0
1165.5 205.0
1166.3 112.0
1169.3 235.0

Annotations:

B^{1,5}X_{Fuc}
1177.5 135.0
1182.4 329.0
1183.2 134.0

Annotations:

^{2,4}A_{GlcNAc}Z B^{0,2}X_{Fuc} B^{2,5}X_{Man}
1183.6 603.0

Annotations:

^{2,4}A_{GlcNAc}Z B^{0,2}X_{Fuc} B^{2,5}X_{Man}
1184.3 237.0
1184.6 104.0
1185.3 376.0

Annotations:

^{2,4}A_{GlcNAc}Y C^{0,4}X_{NeuAc} C^{0,2}X_{Man}
1194.3 528.0
1194.6 424.0
1195.5 266.0
1196.7 107.0
1199.5 113.0

Annotations:

CZ BY
1200.5 104.0
1200.8 135.0
1206.5 216.0
1206.8 154.0
1224.5 315.0

Annotations:

ZZ ZZ
1225.4 395.0
1225.6 283.0
1242.4 120.0

Annotations:

ZY YZ ZY YZ
1242.5 127.0

Annotations:

ZY YZ ZY YZ
1243.5 101.0

Annotations:

B^{0,4}X_{Fuc} B^{1,3}X_{NeuAc} ^{0,2}A_{GlcNAc}Z
1245.4 244.0

Annotations:

C^{2,4}X_{Fuc} ^{2,5}A_{GlcNAc}Y C^{1,3}X_{Fuc} ^{0,2}A_{Man} C^{0,4}X_{Man} C^{1,3}X_{Man} C^{2,4}X_{Man} ^{0,2}A_{GlcNAc}Y
1246.4 172.0
1247.4 101.0

Annotations:

C^{3,5}X_{Fuc}
1249.1 253.0
1287.5 908.0

Annotations:

B
1288.4 167.0

Annotations:

^{1,5}X_{Gal}Y Y^{1,5}X_{Gal} ^{1,5}X_{Fuc}Y Y^{1,5}X_{Fuc}
1288.7 518.0

Annotations:

^{1,5}X_{Gal}Y Y^{1,5}X_{Gal} ^{1,5}X_{Fuc}Y Y^{1,5}X_{Fuc}
1289.4 284.0

Annotations:

C^{1,5}X_{NeuAc}
1305.5 1888.0

Annotations:

C
1306.1 376.0
1306.4 926.0
1307.5 708.0
1308.7 497.0
1329.5 320.0
1331.5 123.0
1333.6 262.0

Annotations:

C^{3,5}X_{NeuAc}
1344.5 108.0

Annotations:

BY CZ
1346.3 177.0

Annotations:

CY
1346.6 302.0

Annotations:

CY
1347.5 382.0

Annotations:

^{2,4}A_{GlcNAc}
1348.6 224.0

Annotations:

Y^{3,5}X_{Fuc} ^{3,5}X_{Fuc}Y
1359.4 106.0
1364.4 115.0
1364.6 114.0
1384.5 235.0
1389.5 381.0

Annotations:

B^{2,4}X_{NeuAc}
1404.4 253.0

Annotations:

ZY YZ ZY YZ
1404.6 337.0

Annotations:

ZY YZ ZY YZ
1405.0 105.0

Annotations:

ZY YZ ZY YZ
1406.4 486.0

Annotations:

Y
1406.6 500.0

Annotations:

Y
1407.3 538.0

Annotations:

C^{2,4}X_{NeuAc} ^{0,2}A_{GlcNAc}
1407.7 945.0

Annotations:

C^{2,4}X_{NeuAc} ^{0,2}A_{GlcNAc}
1408.4 556.0
1408.6 793.0
1409.6 618.0
1410.6 341.0
1412.5 101.0
1431.3 138.0
1451.5 115.0
1467.3 165.0
1472.6 138.0
1473.5 195.0
1475.5 101.0
1490.5 869.0

Annotations:

B
1491.5 715.0
1492.4 101.0

Annotations:

^{0,2}X_{NeuAc}Y Z^{3,5}X_{Fuc} Y^{0,2}X_{NeuAc} ^{3,5}X_{Fuc}Z Y^{2,5}X_{NeuAc}
1508.5 2193.0

Annotations:

C
1509.6 1317.0
1510.6 748.0

Annotations:

Y^{3,5}X_{Fuc} ^{3,5}X_{Fuc}Y
1521.3 122.0
1535.4 129.0
1550.5 158.0

Annotations:

Z
1564.6 149.0

Annotations:

Z^{1,4}X_{NeuAc}
1568.6 1379.0

Annotations:

Y
1569.6 821.0
1570.5 291.0
1570.7 154.0
1571.5 267.0
1571.8 249.0
1572.5 110.0
1572.7 148.0
1588.0 136.0
1589.4 165.0

Annotations:

Z^{1,4}X_{Fuc} Z^{1,4}X_{Fuc}
1610.8 103.0
1635.5 163.0

Annotations:

^{1,3}X_{Fuc}Z ^{2,4}X_{Fuc}Z Z^{1,3}X_{Fuc} Z^{2,4}X_{Fuc} ^{0,4}X_{Man}Z ^{1,3}X_{Man}Z ^{2,4}X_{Man}Z Z^{0,4}X_{Fuc} Z^{0,4}X_{Fuc} Z^{1,3}X_{NeuAc} ^{0,4}X_{Man}Z ^{1,3}X_{Man}Z ^{2,4}X_{Man}Z
1638.5 132.0

Annotations:

^{0,2}X_{NeuAc}
1679.7 165.0

Annotations:

Z
1695.4 266.0

Annotations:

Z Z
1695.7 103.0

Annotations:

Z Z
1696.5 180.0
1696.8 128.0

There are 2 similar spectra:

Id Structure Score

2201

0.77

2202

0.52
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