Recombinant mucin-type fusion proteins with Galα1,3Gal substitution as Clostridium difficile toxin A inhibitors

PubMed Entry

GlyToucan Accession Number: G35679QA

Peak Intensity
262.25 86.2

Annotations:

^{0,4}A_{GalNAc} ^{1,3}A_{GalNAc}Y ^{2,5}X_{Gal}Z
272.14 184.7
276.16 72.4

Annotations:

^{1,4}X_{Gal}Z ^{3,5}A_{GalNAc} Z^{1,4}X_{GlcNAc} ^{0,3}X_{GalNAc}Z
288.09 66.3

Annotations:

^{2,5}A_{GalNAc}Z
290.15 24565.2

Annotations:

B
291.16 1905.4
292.08 43.3

Annotations:

^{0,3}A_{GalNAc} ^{1,4}A_{GalNAc}Y ^{3,5}X_{GalNAc}Z
306.12 33.4

Annotations:

^{1,3}X_{Gal}Z ^{2,4}X_{Gal}Z Z^{1,3}X_{GlcNAc} ^{0,4}X_{GalNAc}Z ^{2,5}A_{GalNAc}Y
308.21 155.1

Annotations:

C
309.1 34.6
312.24 29.2
326.11 26.0
333.94 28.0
334.24 35.2
346.81 26.7

Annotations:

Z^{0,4}X_{GlcNAc} Z^{2,4}X_{GlcNAc}
347.21 216.5

Annotations:

Z^{0,4}X_{GlcNAc} Z^{2,4}X_{GlcNAc}
358.94 26.3

Annotations:

^{1,5}A_{GalNAc}Z
365.29 286.0

Annotations:

Y^{0,4}X_{GlcNAc} Y^{2,4}X_{GlcNAc} ^{2,4}X_{GalNAc}
366.24 232.0

Annotations:

ZY YZ
384.31 67.4

Annotations:

YY
386.01 31.5
386.32 35.2
388.26 92.6
389.26 227.2
390.37 28.8
404.34 133.3
405.16 114.6
406.26 214.6
407.27 14143.6

Annotations:

Z
408.28 1813.7

Annotations:

B^{1,3}X_{NeuAc}
416.18 269.3
424.2 47.8

Annotations:

^{1,5}A_{Gal}
425.29 5896.4

Annotations:

Y
426.28 898.1

Annotations:

C^{1,3}X_{NeuAc}
434.24 389.8
434.94 41.6
435.21 46.6
449.07 37.0

Annotations:

Z^{0,2}X_{GlcNAc}
452.26 37.1

Annotations:

B
453.08 34.8

Annotations:

^{1,5}X_{Gal}
465.23 48.0

Annotations:

Z^{2,5}X_{GlcNAc}
465.59 30.7

Annotations:

Z^{2,5}X_{GlcNAc}
470.42 82.1

Annotations:

C
471.18 80.1
471.44 59.4
483.37 33.8

Annotations:

Y^{2,5}X_{GlcNAc} ^{2,5}X_{Gal}
490.33 26.3
493.25 57.9
505.33 36.1
521.22 32.3

Annotations:

^{1,5}A_{GalNAc}Z
523.38 36.6
527.45 147.6

Annotations:

Y^{0,4}X_{GlcNAc} Y^{2,4}X_{GlcNAc} ^{0,4}X_{Gal}Y ^{1,3}X_{Gal} ^{2,4}X_{Gal}
528.3 30.7
531.29 31.1
535.32 70.0
565.12 30.7
565.41 36.0
566.17 58.8
569.32 220.5

Annotations:

Z
570.41 50.2
583.29 2080.5

Annotations:

^{1,4}A_{GalNAc} ^{3,5}X_{Gal}Z
584.35 322.5
587.33 11478.4

Annotations:

Y
588.33 2150.6
613.1 36.5

Annotations:

^{1,3}X_{NeuAc}Z
613.4 25.7

Annotations:

^{1,3}X_{NeuAc}Z
629.38 52.5
639.24 98.8
639.55 66.4
656.45 27.6
657.35 522.5

Annotations:

Z
658.45 168.8
675.36 319.3

Annotations:

Y
676.39 460.4
677.26 58.5
677.55 48.4
680.4 199.4
710.33 37.9
711.62 30.5
718.35 34.0
758.39 49.6

Annotations:

^{0,2}X_{GlcNAc} ^{0,4}X_{NeuAc}
770.38 132.2
774.5 167.1

Annotations:

^{2,5}X_{GlcNAc}
775.62 40.2

Annotations:

^{0,2}A_{GalNAc}
776.33 32.5
795.34 27.0
800.42 440.5
800.77 122.8
801.42 94.5
812.26 95.5
812.49 38.5
816.25 32.5
816.56 37.7
817.41 147.9
818.42 907.6

Annotations:

^{0,4}X_{GlcNAc} ^{2,4}X_{GlcNAc} ^{0,4}X_{Gal}
819.2 98.6
819.5 144.5
834.56 611.7

Annotations:

^{1,3}X_{NeuAc}
835.5 206.7
842.51 91.5

There are 8 similar spectra:

Id Structure Score

3061

1.00

191

1.00

2640

1.00

3663

0.99

105

0.88

2658

0.87

2657

0.69

3060

0.59
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