Recombinant mucin-type fusion proteins with Galα1,3Gal substitution as Clostridium difficile toxin A inhibitors

PubMed Entry

GlyToucan Accession Number: G40269CS

Peak Intensity
192.41 7.5
194.09 24.1
199.8 9.6
202.13 7.1
204.07 304.9

Annotations:

Z
205.11 12.6
210.0 22.1
212.1 38.4
220.14 28.3
222.11 192.6

Annotations:

Y
223.23 17.0
226.05 6.9
230.19 8.1
238.15 9.3
246.05 30.1
250.06 17.4

Annotations:

^{1,5}X_{Gal}
254.04 8.8
256.16 6.9
263.0 6.7

Annotations:

^{0,2}A_{GalNAc}Z
268.0 17.5
268.29 11.1
270.23 13.1
271.25 12.1
272.11 240.4
273.18 43.3
274.23 8.9

Annotations:

^{1,4}A_{GalNAc}Z
276.1 34.8

Annotations:

^{0,3}X_{Gal}Z ^{0,3}X_{GalNAc}Z
288.1 42.0
290.16 26246.0

Annotations:

B
291.15 2696.6
292.09 7.4

Annotations:

^{1,4}A_{GalNAc}Y ^{3,5}X_{Gal}Z ^{3,5}X_{GalNAc}Z
292.44 10.5

Annotations:

^{1,4}A_{GalNAc}Y ^{3,5}X_{Gal}Z ^{3,5}X_{GalNAc}Z
306.22 8.7

Annotations:

^{0,4}X_{Gal}Z ^{0,4}X_{GalNAc}Z
308.18 25.3

Annotations:

C
309.34 8.4
324.15 31.7

Annotations:

^{0,4}X_{Gal}Y ^{1,3}X_{Gal} ^{2,4}X_{Gal} ^{0,4}X_{GalNAc}Y
328.99 20.2
331.8 8.4

Annotations:

B^{0,4}X_{NeuAc}
332.2 7.8

Annotations:

B^{0,4}X_{NeuAc}
334.09 15.1
342.31 10.4
346.16 17.9
360.18 7.4
366.41 20.7

Annotations:

Z
376.35 42.1
380.21 302.8

Annotations:

C^{0,3}X_{Gal} ^{1,4}A_{Gal}
381.27 19.0
384.23 1096.9

Annotations:

Y
385.25 132.0
386.32 34.2
387.87 17.8
388.14 21.3
398.19 25.2
404.17 39.6
405.19 22.5
406.19 30.3
407.2 6.8
408.27 67.1

Annotations:

B^{1,3}X_{NeuAc}
410.33 33.7

Annotations:

C^{0,4}X_{Gal} ^{0,2}A_{Gal}
416.21 65.4
434.25 78.9
436.05 8.0
436.27 6.7
452.23 24.3

Annotations:

B
452.43 27.6

Annotations:

B
454.43 94.1

Annotations:

^{0,2}X_{NeuAc}
455.29 22.8
455.54 14.6
464.31 9.3
470.26 66.9

Annotations:

C
471.22 207.1
472.37 12.4
477.25 38.7
477.67 15.0
495.5 9.7
508.46 9.5
512.16 7.7

Annotations:

^{2,4}A_{GalNAc}
513.28 10.7
527.06 13.3
537.24 8.6
567.3 14.0
567.65 7.2
571.53 9.3
595.4 12.7
596.36 9.8
597.17 31.6
597.49 28.5
598.6 21.8
609.14 8.7
612.84 9.3
614.35 71.3
615.42 37.5

Annotations:

^{0,4}X_{Gal} ^{0,4}X_{GalNAc}
615.96 11.0
627.52 12.7

Annotations:

^{1,5}A_{GalNAc}
627.93 9.1
629.17 8.7
631.32 222.4

Annotations:

^{1,3}X_{NeuAc}
632.24 18.5
632.55 23.4
641.34 17.4

There are 16 similar spectra:

Id Structure Score

2604

1.00

3042

1.00

74

1.00

3653

1.00

3637

0.99

2814

0.99

147

0.99

98

0.99

452

0.98

3636

0.95

3652

0.91

3041

0.90

2603

0.89

180

0.89

451

0.72

96

0.53
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